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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Wingless-type family member 5A (Wnt-5a) stimulates synaptic differentiation and function of glutamatergic synapses
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Wingless-type family member 5A (Wnt-5a) stimulates synaptic differentiation and function of glutamatergic synapses

机译：无翅型家族成员5A（Wnt-5a）刺激突触分化和谷氨酸能突触的功能。

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摘要

Growing evidence indicates that Wingless-type (Wnt) signaling plays an important role in the maturation of the central nervous system. We report here that Wingless-type family member 5A (Wnt-5a) is expressed early in development and stimulates den-drite spine morphogenesis, inducing de novo. formation of spines and increasing the size of the preexisting ones in hippocampal neurons. Wnt-5a increased intracellular calcium concentration in dendritic processes and the amplitude of NMDA spontaneous miniature currents. Acute application of Wnt-5a increased the amplitude of field excitatory postsynaptic potentials (fEPSP) in hippocampal slices, an effect that was prevented by calcium-channel blockers. The physiological relevance of our findings is supported by studies showing that Wnt scavengers decreased spine density, miniature excitatory postsynaptic currents, and fEPSP amplitude. We conclude that Wnt-5a stimulates different aspects of synaptic differentiation and plasticity in the mammalian central nervous system.
机译：越来越多的证据表明，无翼型（Wnt）信号在中枢神经系统的成熟中起着重要作用。我们在这里报告说，无翅型家庭成员5A（Wnt-5a）在发育早期表达并刺激树突状树突形态发生，从头诱导。形成棘突并增加海马神经元中先前存在的棘突的大小。 Wnt-5a增加了树突状过程中细胞内钙的浓度以及NMDA自发微型电流的幅度。急性应用Wnt-5a会增加海马片中的场兴奋性突触后突触电位（fEPSP）的幅度，这种作用被钙通道阻滞剂所阻止。研究表明，Wnt清除剂降低了脊柱密度，微型兴奋性突触后突触电流和fEPSP振幅，这些结果支持了我们发现的生理相关性。我们得出结论，Wnt-5a刺激哺乳动物中枢神经系统中突触分化和可塑性的不同方面。

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    Lorena Varela-Nallar; Ivan E. Alfaro; Felipe G. Serrano; Jorge Parodi; Nibaldo C. Inestrosa;

  • 作者单位

    Centro de Envejecimiento y Regeneracion, Departamento de Biologia Celular y Molecular, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Santiago 8331150, Chile;

    Centro de Envejecimiento y Regeneracion, Departamento de Biologia Celular y Molecular, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Santiago 8331150, Chile;

    Centro de Envejecimiento y Regeneracion, Departamento de Biologia Celular y Molecular, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Santiago 8331150, Chile;

    Centro de Envejecimiento y Regeneracion, Departamento de Biologia Celular y Molecular, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Santiago 8331150, Chile;

    Centro de Envejecimiento y Regeneracion, Departamento de Biologia Celular y Molecular, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Santiago 8331150, Chile;

  • 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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