Specific erythroid-lineage defect in mice conditionally deficient for Mediator subunit Med1

Melanie Stumpf; Xiaojing Yue; Sandra Schmitz; Herve Luche; Janardan K. Reddy; Tilman Borggrefe

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Specific erythroid-lineage defect in mice conditionally deficient for Mediator subunit Med1

机译：有条件地缺乏介体Med1亚基的小鼠中的特定类红系谱系缺陷

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The Mediator complex forms the bridge between transcriptional activators and the RNA polymerase II. Med1 (also known as PBP or TRAP220) is a key component of Mediator that interacts with nuclear hormone receptors and GATA transcription factors. Here, we show dynamic recruitment of GATA-1, TFIIB, Mediator, and RNA polymerase II to the β-globin locus in induced mouse erythoid leukemia cells and in an erythropoietin-inducible hematopoietic progenitor cell line. Using Med1 conditional knockout mice, we demonstrate a specific block in erythroid development but not in myeloid or lymphoid development, highlighted by the complete absence of β-globin gene expression. Thus, Mediator subunit Med1 plays a pivotal role in erythroid development and in β-globin gene activation.

机译：介体复合物形成转录激活剂和RNA聚合酶II之间的桥梁。 Med1（也称为PBP或TRAP220）是介体的关键组件，可与核激素受体和GATA转录因子相互作用。在这里，我们显示在诱导的小鼠类红细胞白血病细胞和促红细胞生成素诱导的造血祖细胞系中，将GATA-1，TFIIB，介体和RNA聚合酶II动态募集到β-球蛋白基因座。使用Med1条件性基因敲除小鼠，我们证明了类红细胞发育中的特定阻滞，但在髓样或淋巴样发育中却没有，具体表现为完全缺乏β-珠蛋白基因表达。因此，介体亚基Med1在红系发育和β-珠蛋白基因激活中起着关键作用。

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来源
《Proceedings of the National Academy of Sciences of the United States of America》 |2010年第50期|p.21541-21546|共6页
作者
Melanie Stumpf; Xiaojing Yue; Sandra Schmitz; Herve Luche; Janardan K. Reddy; Tilman Borggrefe;
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作者单位

Max-Planck-lnstitute of Immunobiology, 79108 Freiburg, Germany;

Max-Planck-lnstitute of Immunobiology, 79108 Freiburg, Germany,Faculty of Biology, University of Freiburg, 79104 Freiburg, Germany;

Max-Planck-lnstitute of Immunobiology, 79108 Freiburg, Germany;

Centre d'lmmunologie de Marseille-Luminy, Universite de la Mediterranee, Centre National de la Recherche Scientifique, Unite Mixte de Recherche 631,13288Marseille, France;

Department of Pathology, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611;

Max-Planck-lnstitute of Immunobiology, 79108 Freiburg, Germany;

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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类
关键词
blood; hematopoiesis; erythropoiesis; transcriptional regulation; globin;

机译：血液;造血;红细胞生成;转录调控;球蛋白;

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1. Conditional ablation of mediator subunit MED1 (MED1/PPARBP) gene in mouse liver attenuates glucocorticoid receptor agonist dexamethasone-induced hepatic steatosis. [J] . Jia Y, Viswakarma N, Fu T Gene expression . 2008,第5期

机译：小鼠肝脏中条件调节子亚基MED1（MED1 / PPARBP）基因的消融减弱了糖皮质激素受体激动剂地塞米松诱导的肝脂肪变性。
2. Estrogen receptor coactivator Mediator Subunit 1 (MED1) as a tissue-specific therapeutic target in breast cancer [J] . Marissa Leonard, Xiaoting Zhang Journal of Zhejiang University. Science, B . 2019,第5期

机译：雌激素受体共激活因子介体亚基1（MED1）作为乳腺癌的组织特异性治疗靶标
3. PRDM16 enhances nuclear receptor-dependent transcription of the brown fat- specific Ucp1 gene through interactions with Mediator subunit MED1 [J] . Iida Satoshi, Chen Wei, Nakadai Tomoyoshi, Genes and Development: a Journal Devoted to the Molecular Analysis of Gene Expression in Eukaryotes, Prokaryotes, and Viruses . 2015,第3期

机译：PRDM16通过与介体亚基MED1的相互作用增强棕色脂肪特异性Ucp1基因的核受体依赖性转录。
4. Localization of the Specific Site of Enzyme-Mediated Covalent Binding of Phycoerythrobilin (PEB) to C-Phycoerythrin Beta Subunit [C] . M. Nazim Boutaghou, Avijit Biswas, Wendy M. Schluchter, American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2011

机译：酶介导的植物植物（PEB）与C-Phycooerythronβ亚基的酶介导的共价结合的定位
5. Contrasting defects in lymphangiogenic remodeling and lymphangiogenesis revealed in Angiopoietin-2 deficient and Vegfc hemizygous mice [D] . Dellinger, Michael Thomas, Jr. 2008

机译：血管生成素2缺乏和Vegfc半合子小鼠中发现的淋巴管生成重塑和淋巴管生成的相反缺陷
6. Specific erythroid-lineage defect in mice conditionally deficient for Mediator subunit Med1 [O] . Melanie Stumpf, Xiaojing Yue, Sandra Schmitz, 2010

机译：有条件地缺乏介体Med1亚基的小鼠中的特定类红系谱系缺陷
7. Specific erythroid-lineage defect in mice conditionally deficient for Mediator subunit Med1 [O] . Stumpf, Melanie, Yue, Xiaojing, Schmitz, Sandra, 2010

机译：有条件地缺乏介体Med1亚基的小鼠中的特定类红系谱系缺陷
8. Receptor-Mediated Elimination of Phosphocholine-Specific B Cells in X-LinkedImmune-Deficient Mice [R] . Kenny, J. J., Stall, A. M., Sieckmann, D. G., 1991

机译：受体介导的X-连锁免疫缺陷小鼠中磷酸胆碱特异性B细胞的消除

Specific erythroid-lineage defect in mice conditionally deficient for Mediator subunit Med1

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