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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Natural selection in a contemporary human population
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Natural selection in a contemporary human population

机译：当代人口的自然选择

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Our aims were to demonstrate that natural selection is operating on contemporary humans, predict future evolutionary change for specific traits with medical significance, and show that for some traits we can make short-term predictions about our future evolution. To do so, we measured the strength of selection, estimated genetic variation and covariation, and predicted the response to selection for women in the Framingham Heart Study, a project of the National Heart, Lung, and Blood Institute and Boston University that began in 1948. We found that natural selection is acting to cause slow, gradual evolutionary change. The descendants of these women are predicted to be on average slightly shorter and stouter, to have lower total cholesterol levels and systolic blood pressure, to have their first child earlier, and to reach menopause later than they would in the absence of evolution. Selection is tending to lengthen the reproductive period at both ends. To better understand and predict such changes, the design of planned large, long-term, multicohort studies should include input from evolutionary biologists.
机译：我们的目的是证明自然选择对当代人类起作用，预测具有医学意义的特定性状的未来进化变化，并表明对于某些性状我们可以对我们的未来进化进行短期预测。为此，我们在1948年开始的美国国家心脏，肺与血液研究所和波士顿大学的弗雷明汉心脏研究中，测量了选择的强度，估计的遗传变异和协变，并预测了女性对选择的反应。我们发现自然选择正在导致缓慢的，渐进的进化变化。与没有进化的情况相比，预计这些妇女的后代平均会矮一些，更健壮，总胆固醇水平和收缩压更低，第一个孩子更早，更年期更晚。选择趋于延长两端的生育期。为了更好地理解和预测这种变化，计划中的大型，长期，多队列研究的设计应包括进化生物学家的意见。

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