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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Nodal Points And Complexity Of Notch-rassignal Integration
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Nodal Points And Complexity Of Notch-rassignal Integration

机译：节点-积分信号的节点和复杂性

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摘要

Metazoans use a handful of highly conserved signaling pathways to create a signaling backbone that governs development. How these few signals have such a versatile action likely depends upon the larger-scale network they form through integration, as exemplified by cross-talk between the Notch and receptor tyrosine kinase (RTK) pathways. We examined the transcriptional output of Notch-RTK cross-talk during Drosophila development and present in vivo data supporting a role for selected mutually regulated genes in signal integration. Interestingly, Notch-RTK integration did not lead to general antagonism of either pathway, as is commonly believed. Instead, integration had a combinatorial effect on specific cross-regulated targets, which unexpectedly included numerous core components of the RTK and other major signaling pathways (TGF-β, Hh, Jak/Stat, nuclear receptor and Wnt). We find the majority of Ras-responsive genes are also Notch-responsive, suggesting Notch may function to specify the response to Ras activation.
机译：后生动物使用少数高度保守的信号传导途径来创建控制发育的信号传导主链。这几个信号如何具有如此广泛的作用可能取决于它们通过整合形成的大规模网络，例如Notch和受体酪氨酸激酶（RTK）途径之间的串扰就是例证。我们检查了果蝇发育过程中Notch-RTK串扰的转录输出，并提出了体内数据，该数据支持选定的相互调节基因在信号整合中的作用。有趣的是，Notch-RTK的整合并没有引起任何一种途径的普遍拮抗作用，这是众所周知的。相反，整合对特定的交叉调控靶标具有组合作用，该靶标意外地包括RTK的许多核心成分和其他主要信号传导途径（TGF-β，Hh，Jak / Stat，核受体和Wnt）。我们发现大多数Ras反应性基因也对Notch反应，这表明Notch可能发挥作用，以指定对Ras激活的反应。

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