Thirteen posttranslational modifications convert a 14-residue peptide into the antibiotic thiocillin

Laura C. Wieland Brown; Michael G. Acker; Jon Clardy; Christopher T. Walsh; Michael A. Fischbach

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Thirteen posttranslational modifications convert a 14-residue peptide into the antibiotic thiocillin

机译：十三种翻译后修饰将14个残基的肽转化为抗生素thiocillin

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The thiazolylpeptides are a family of >50 bactericidal antibiotics that block the initial steps of bacterial protein synthesis. Here, we report a biosynthetic gene cluster for thiocillin and establish that it, and by extension the whole class, is ribosomally synthesized. Remarkably, the C-terminal 14 residues of a 52-residue peptide precursor undergo 13 posttranslational modifications to give rise to thiocillin, making this antibiotic the most heavily posttranslationally-modified peptide known to date.

机译：噻唑肽是一类> 50种杀菌抗生素，可阻止细菌蛋白质合成的初始步骤。在这里，我们报告了硫代西林的生物合成基因簇，并确定它和通过扩展整个类是核糖体合成的。值得注意的是，一个52个残基的肽前体的C末端14个残基经过13个翻译后修饰，生成thiocillin，使该抗生素成为迄今为止已知的最重的翻译后修饰肽。

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来源
《Proceedings of the National Academy of Sciences of the United States of America》 |2009年第8期|2549-2553|共5页
作者
Laura C. Wieland Brown; Michael G. Acker; Jon Clardy; Christopher T. Walsh; Michael A. Fischbach;
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作者单位

Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114 Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115;

Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115;

Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115;

Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115;

Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114;

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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类
关键词
biosynthesis; natural products; thiazolylpeptides;

机译：生物合成天然产物;噻唑肽;

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6. Thirteen posttranslational modifications convert a 14-residue peptide into the antibiotic thiocillin [O] . Laura C. Wieland Brown, Michael G. Acker, Jon Clardy, 2009

机译：十三种翻译后修饰将14个残基的肽转化为抗生素thiocillin
7. Thirteen posttranslational modifications convert a 14-residue peptide into the antibiotic thiocillin [O] . Wieland Brown, Laura C., Acker, Michael G., Clardy, Jon, 2009

机译：十三种翻译后修饰将14个残基的肽转化为抗生素thiocillin

Thirteen posttranslational modifications convert a 14-residue peptide into the antibiotic thiocillin

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