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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >The G protein-coupled receptor FSHR-1 is required for the Caenorhahditis elegans innate immune response
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The G protein-coupled receptor FSHR-1 is required for the Caenorhahditis elegans innate immune response

机译：秀丽隐杆线虫先天免疫应答需要G蛋白偶联受体FSHR-1

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摘要

Innate immunity is an ancient defense system used by both vertebrates and invertebrates. Previously characterized innate immune responses in plants and animals are triggered by detection of pathogens using specific receptors, which typically use a leucine-rich repeat (LRR) domain to bind molecular patterns associated with infection. The nematode Caenorhabditis elegans uses defense pathways conserved with vertebrates; however, the mechanism by which C. Elegans detects pathogens is unknown. We screened all LRR-containing transmembrane receptors in C elegans and identified the G protein-coupled receptor FSHR-1 as an important component of the C elegans immune response to Gram-negative and Gram-positive bacterial pathogens. FSHR-1 acts in the C. Elegans intestine, the primary site of exposure to ingested pathogens. FSHR-1 signals in parallel to the known p38 MAPK pathway but converges to regulate the transcrip-tional induction of an overlapping but nonidentical set of antimicrobial effectors. FSHR-1 may act generally to boost the nematode immune response, or it may function as a pathogen receptor.
机译：先天免疫是脊椎动物和无脊椎动物都使用的古老防御系统。通过使用特异性受体检测病原体，可以触发动植物先前固有的先天免疫应答，该受体通常使用富含亮氨酸的重复序列（LRR）域结合与感染相关的分子模式。线虫秀丽隐杆线虫利用脊椎动物保守的防御途径。但是，秀丽隐杆线虫检测病原体的机制尚不清楚。我们筛选了秀丽隐杆线虫中所有包含LRR的跨膜受体，并将G蛋白偶联受体FSHR-1确定为秀丽隐杆线虫对革兰氏阴性和革兰氏阳性细菌病原体免疫应答的重要组成部分。 FSHR-1在秀丽隐杆线虫小肠中起作用，这是暴露于摄入的病原体的主要部位。 FSHR-1信号与已知的p38 MAPK途径平行，但会聚在一起以调节重叠但不相同的一组抗菌效应子的转录诱导。 FSHR-1通常可以增强线虫的免疫反应，或者可以充当病原体受体。

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  • 作者

    Jennifer R. Powell; Dennis H. Kim; Frederick M. Ausubel;

  • 作者单位

    Department of Genetics, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115 Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114 Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, MA 02114;

    Department of Genetics, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115 Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114;

    Department of Genetics, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115 Department of Molecular Biology, 77 Avenue Louis Pasteur, Boston, MA 02115 Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, MA 02114;

  • 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    host-pathogen interactions; leucine-rich repeat;

    机译：宿主-病原体相互作用;富含亮氨酸的重复;

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