TOX3 regulates calcium-dependent transcription in neurons

Shauna H. Yuan; Zilong Qiu; Anirvan Ghosh

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TOX3 regulates calcium-dependent transcription in neurons

机译：TOX3调节神经元中钙依赖性转录

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摘要

We report the cloning and characterization of TOX3, a high mobility group box protein involved in mediating calcium-dependent transcription. TOX3 was identified as a calcium-dependent transactivator using the Transactivator Trap screen. We find that TOX3 interacts with both cAMP response element (CRE)-binding protein (CREB) and CREB-binding protein (CBP), and knockdown of the endogenous TOX3 by RNAi leads to significant reduction of calcium-induced c-fos expression and complete inhibition of calcium activation of the c-fos promoter. The effects of TOX3 on calcium-dependent transcription require the CRE elements. These observations identify TOX3 as an important regulator of calcium-dependent transcription and suggest that TOX3 exerts its effect on CRE-mediated transcription via its association with the CREB-CBP complex.

机译：我们报告了TOX3的克隆和鉴定，TOX3是参与介导钙依赖性转录的高迁移率族框蛋白。使用Transactivator Trap屏幕将TOX3鉴定为钙依赖性反式激活剂。我们发现，TOX3与cAMP反应元件（CRE）结合蛋白（CREB）和CREB结合蛋白（CBP）相互作用，并且通过RNAi敲除内源性TOX3导致钙诱导的c-fos表达和完全减少抑制c-fos启动子的钙激活。 TOX3对钙依赖性转录的影响需要CRE元件。这些观察结果确定TOX3是钙依赖性转录的重要调节剂，并暗示TOX3通过与CREB-CBP复合物的缔合而对CRE介导的转录发挥作用。

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《Proceedings of the National Academy of Sciences of the United States of America》 |2009年第8期|2909-2914|共6页
作者
Shauna H. Yuan; Zilong Qiu; Anirvan Ghosh;
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作者单位

Department of Neuroscience, Division of Biological Sciences, University of California at San Diego, La Jolla, CA 92093-0366;

Neurobiology Section, Division of Biological Sciences, University of California at San Diego, La Jolla, CA 92093-0366;

Neurobiology Section, Division of Biological Sciences, University of California at San Diego, La Jolla, CA 92093-0366;

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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类
关键词
CBP; CREB; c-fos; activity;

机译：CBP;CREB;c-fos;活动;

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1. The global regulator of pathogenesis PnCon7 positively regulates Tox3 Tox3 effector gene expression through direct interaction in the wheat pathogen Parastagonospora nodorum Parastagonospora nodorum [J] . Lin Shao‐Yu, Chooi Yit‐Heng, Solomon Peter S. Molecular Microbiology . 2018,第1期

机译：通过小麦病原体Parastagonpora Nodorum Parastagonpora Nodorum的直接相互作用，致病机制PnCon7的全局调节剂通过直接相互作用来呈正调节至X3染料3效应基因表达
2. TOX3 is a neuronal survival factor that induces transcription depending on the presence of CITED1 or phosphorylated CREB in the transcriptionally active complex. [J] . Dittmer S, Kovacs Z, Yuan SH, Journal of Cell Science . 2011,第2期

机译：TOX3是一种神经元存活因子，可根据转录活性复合物中CITED1或磷酸化的CREB的存在诱导转录。
3. Kisspeptin excites gonadotropin-releasing hormone neurons through a phospholipase C/calcium-dependent pathway regulating multiple ion channels. [J] . Liu X, Lee K, Herbison AE Endocrinology . 2008,第9期

机译：Kisspeptin通过调节多个离子通道的磷脂酶C /钙依赖性途径激发促性腺激素释放激素神经元。
4. Accurate analog VLSI model of calcium-dependent bursting neurons [C] . Laflaquiere, A., Le Masson, . 1997

机译：钙依赖性爆发性神经元的精确模拟VLSI模型
5. CALCIUM-DEPENDENT PROTEIN PHOSPHORYLATION AND THE REGULATION OF ELECTRICAL EXCITABILITY IN THE BAG CELL NEURONS OF APLYSIA (PHORBOL, CALMODULIN, PROTEIN KINASE C). [D] . DERIEMER, SUSAN ALYN. 1984

机译：依赖钙的蛋白质磷酸化和APLYSIA袋细胞神经元中电兴奋性的调节（酚，钙调蛋白，蛋白激酶C）。
6. TOX3 regulates calcium-dependent transcription in neurons [O] . Shauna H. Yuan, Zilong Qiu, Anirvan Ghosh 2009

机译：TOX3调节神经元中钙依赖性转录
7. TOX3 regulates calcium-dependent transcription in neurons [O] . Yuan, Shauna H., Qiu, Zilong, Ghosh, Anirvan 2009

机译：TOX3调节神经元中钙依赖性转录

TOX3 regulates calcium-dependent transcription in neurons

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