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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Early childhood stress is associated with elevated antibody levels to herpes simplex virus type 1
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Early childhood stress is associated with elevated antibody levels to herpes simplex virus type 1

机译：儿童早期压力与1型单纯疱疹病毒抗体水平升高有关

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摘要

It is well known that children need solicitous parenting and a nurturing rearing environment to ensure their normal behavioral development. Early adversity often negatively impacts emotional and mental well-being, but it is less clearly established how much the maturation and regulation of physiological systems is also compromised. The following research investigated the effect of 2 different types of adverse childhood experiences, early deprivation through institutionalization and physical abuse, on a previously unexplored outcome: the containment of herpes simplex virus (HSV). The presence of HSV-specific antibody in salivary specimens was determined in 155 adolescents, including 41 postinstitution-alized, 34 physically-abused, and 80 demographically-similar control youth. Across 4 school and home days, HSV antibody was higher in both postinstitutionalized and physically-abused adolescents when compared with control participants. Because the prevalence of HSV infection was similar across the groups, the elevated antibody was likely indicative of viral recrudescence from latency. Total (Secretory Ig-A secretion was associated with HSV, but did not account for the group differences in HSV-specific antibody. These findings are likely caused by a failure of cellular immune processes to limit viral reactivation, indicating a persistent effect of early rearing on immune functioning. The fact that antibody profiles were still altered years after adoption into a more benevolent setting with supportive families suggests these results were not caused by contemporaneous factors, but rather reflect a lingering influence of earlier life experiences.
机译：众所周知，儿童需要认真的养育子女和良好的养育环境，以确保其正常的行为发展。早期逆境通常会对情绪和心理健康产生负面影响，但尚不清楚是否会损害生理系统的成熟和调节。以下研究调查了两种不同类型的不利儿童时期经历，即通过机构化和身体虐待导致的早期剥夺，对先前无法探索的结果：单纯疱疹病毒的遏制（HSV）的影响。在155名青少年中确定了唾液标本中HSV特异性抗体的存在，其中包括41名机构化后的青少年，34名遭受身体虐待的青少年和80名人口统计学上相似的对照青年。在4个学校和家庭日中，与对照组相比，入院后和身体虐待的青少年中HSV抗体较高。由于各组之间HSV感染的患病率相似，因此抗体升高可能表明潜伏期导致病毒复发。总的（分泌的Ig-A分泌与HSV相关，但不能解释HSV特异性抗体的组差异。这些发现可能是由于细胞免疫过程未能限制病毒的再激活所致，表明了早期饲养的持续作用抗体谱在采用支持性家庭的更仁慈环境中仍然存在多年的变化，这一事实表明这些结果不是由同时期因素引起的，而是反映了早期生活经历的持续影响。

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