The human forkhead box O3A (FOXO3A) protein is part of the insulin-IGFl signaling pathway and helps regulate metabolism and lifespan. Although recent research found an association between longevity and 3 single nucleotide polymorphisms (SNPs) in FOXO3A in Japanese Americans, the results had not been replicated in an independent population. In a sample of 1,762 German centenarians, nonagenarians, and younger control subjects, Friederike Flachsbart et al. Confirmed the association between longevity and FOXO3A SNPs.
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