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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Circadian oscillation of nucleotide excision repair in mammalian brain
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Circadian oscillation of nucleotide excision repair in mammalian brain

机译:哺乳动物脑中核苷酸切除修复的昼夜节律振荡

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摘要

The circadian clock regulates the daily rhythms in the physiology and behavior of many organisms, including mice and humans. These cyclical changes at molecular and macroscopic levels affect the organism's response to environmental stimuli such as light and food intake and the toxicity and efficacy of chemo- and radiother-apeutic agents. In this work, we investigated the circadian behavior of the nucleotide excision repair capacity in the mouse cerebrum to gain some insight into the optimal circadian time for favorable therapeutic response with minimal side effects in cancer treatment with chemotherapeutic drugs that produce bulky ad-ducts in DNA. We find that nucleotide excision repair activity in the mouse cortex is highest in the afternoon/evening hours and is at its lowest in the night/early morning hours. The circadian oscillation of the repair capacity is caused at least in part by the circadian oscillation of the xeroderma pigmentosum A DNA damage recognition protein.
机译:昼夜节律调节许多生物的生理和行为的日常节律,包括小鼠和人类。这些在分子和宏观水平上的周期性变化影响生物体对环境刺激的反应,例如光和食物的摄入,以及化学和放射治疗药物的毒性和功效。在这项工作中,我们研究了小鼠大脑中核苷酸切除修复能力的昼夜节律行为,以期获得最佳的昼夜节律时间,以最佳的治疗反应,以最小的副作用在化学治疗药物中产生大量DNA加合物的癌症治疗中。我们发现,小鼠皮层中的核苷酸切除修复活性在下午/傍晚时最高,而在夜间/清晨时最低。修复能力的昼夜节律振荡至少部分是由干燥皮色素A DNA损伤识别蛋白的昼夜节律振荡引起的。

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