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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Interaction Forces And Adhesion Of Supported Myelin Lipid Bilayers Modulated By Myelin Basic Protein
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Interaction Forces And Adhesion Of Supported Myelin Lipid Bilayers Modulated By Myelin Basic Protein

机译：髓磷脂碱性蛋白调节的相互作用的相互作用力和粘附的支持的髓磷脂脂质双层。

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摘要

Force-distance measurements between supported lipid bilayers mimicking the cytoplasmic surface of myelin at various surface coverages of myelin basic protein (MBP) indicate that maximum adhesion and minimum cytoplasmic spacing occur when each negative lipid in the membrane can bind to a positive arginine or lysine group on MBP. At the optimal lipid/protein ratio, additional attractive forces are provided by hydrophobic, van der Waals, and weak dipolar interactions between zwitterionic groups on the lipids and MBP. When MBP is depleted, the adhesion decreases and the cytoplasmic space swells; when MBP is in excess, the bilayers swell even more. Excess MBP forms a weak gel between the surfaces, which collapses on compression. The organization and proper functioning of myelin can be understood in terms of physical noncovalent forces that are optimized at a particular combination of both the amounts of and ratio between the charged lipids and MBP. Thus loss of adhesion, possibly contributing to demyelination, can be brought about by either an excess or deficit of MBP or anionic lipids.
机译：在髓磷脂碱性蛋白（MBP）的各种表面覆盖率下模拟髓磷脂质膜表面的支持脂质双层之间的力距测量表明，当膜中的每个负脂质都可以与阳性精氨酸或赖氨酸基团结合时，会出现最大的粘附力和最小的胞质间隔在MBP上。在最佳脂质/蛋白质比率下，脂质，MBP上的两性离子基团之间的疏水性，范德华力和弱的偶极相互作用提供了额外的吸引力。 MBP耗尽后，黏附力降低，胞质空间膨胀；当MBP过量时，双层会进一步膨胀。过量的MBP在表面之间形成弱凝胶，压缩后会塌陷。可以根据物理非共价力来理解髓磷脂的组织和适当功能，所述物理非共价力在带电脂质和MBP的量和比率之间的特定组合下被优化。因此，MBP或阴离子脂质的过量或不足都会导致可能导致脱髓鞘的粘附力下降。

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