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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Sessile hemocytes as a hematopoietic compartment in Drosophila melanogaster
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Sessile hemocytes as a hematopoietic compartment in Drosophila melanogaster

机译：无花果血细胞在果蝇中作为造血室

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摘要

The blood cells, or hemocytes, in Drosophila participate in the immune response through the production of antimicrobial pep-tides, the phagocytosis of bacteria, and the encapsulation of larger foreign particles such as parasitic eggs; these immune reactions are mediated by phylogenetically conserved mechanisms. The encapsulation reaction is analogous to the formation of granuloma in vertebrates, and is mediated by large specialized cells, the lamel-locytes. The origin of the lamellocytes has not been formally established, although it has been suggested that they are derived from the lymph gland, which is generally considered to be the main hematopoietic organ in the Drosophila larva. However, it was recently observed that a subepidermal population of sessile blood cells is released into the circulation in response to a parasitoid wasp infection. We set out to analyze this phenomenon systematically. As a result, we define the sessile hemocytes as a novel hematopoietic compartment, and the main source of lamellocytes.
机译：果蝇中的血细胞或血细胞通过产生抗菌肽，吞噬细菌以及包裹较大的外来颗粒（如寄生卵）来​​参与免疫反应。这些免疫反应是由系统发育保守的机制介导的。包封反应类似于脊椎动物中肉芽肿的形成，并且由大型专门细胞即层状细胞介导。尚没有正式确定lamellocytes的起源，尽管有人提出它们起源于淋巴腺，而淋巴腺通常被认为是果蝇幼虫的主要造血器官。然而，最近观察到，响应于寄生性类黄蜂感染，表皮下的无柄血细胞群被释放到循环中。我们着手系统地分析这种现象。因此，我们将无柄血细胞定义为一种新型的造血区室，并且是lamellocytes的主要来源。

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  • 作者

    Robert Markus; Barbara Laurinyecz; Eva Kurucz; Viktor Honti; Izabella Bajusz; Botond Sipos; Kalman Somogyi; Jesper Kronhamn; Dan Hultmark; Istvan Ando;

  • 作者单位

    Institute of Genetics, Biological Research Center of the Hungarian Academy of Sciences, P.O. Box 521, H-6701, Szeged, Hungary;

    Institute of Genetics, Biological Research Center of the Hungarian Academy of Sciences, P.O. Box 521, H-6701, Szeged, Hungary;

    Institute of Genetics, Biological Research Center of the Hungarian Academy of Sciences, P.O. Box 521, H-6701, Szeged, Hungary;

    Institute of Genetics, Biological Research Center of the Hungarian Academy of Sciences, P.O. Box 521, H-6701, Szeged, Hungary;

    Institute of Genetics, Biological Research Center of the Hungarian Academy of Sciences, P.O. Box 521, H-6701, Szeged, Hungary;

    Institute of Genetics, Biological Research Center of the Hungarian Academy of Sciences, P.O. Box 521, H-6701, Szeged, Hungary;

    Institute of Genetics, Biological Research Center of the Hungarian Academy of Sciences, P.O. Box 521, H-6701, Szeged, Hungary;

    Department of Molecular Biology, Umea University, S-901 87 Umea, Sweden;

    Department of Molecular Biology, Umea University, S-901 87 Umea, Sweden;

    Institute of Genetics, Biological Research Center of the Hungarian Academy of Sciences, P.O. Box 521, H-6701, Szeged, Hungary;

  • 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    cellular immunity; lamellocytes; parasitoid wasp; plasmatocytes; niche;

    机译：细胞免疫毛细胞寄生蜂浆细胞利基市场;

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