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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Cydophilin 40 is required for microRNA activity in Arabidopsis
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Cydophilin 40 is required for microRNA activity in Arabidopsis

机译：拟南芥中的microRNA活性需要Cydophilin 40

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摘要

Loss-of-function mutations of SQUINT (SQN)-which encodes the Arabidopsis orthologue of cydophilin 40 (CyP40)-cause the precocious expression of adult vegetative traits, an increase in carpel number, and produce abnormal spacing of flowers in the inflorescence. Here we show that the vegetative phenotype of sqn is attributable to the elevated expression of miR156-regulated members of the SPL family of transcription factors and provide evidence that this defect is a consequence of a reduction in the activity of ARGONAUTE1 (AGO1). Support for this latter conclusion was provided by the phenotypic similarity between hypomorphic al-leles of AGO1 and null alleles of SQN and by the genetic interaction between sqn and these alleles. Our results suggest that AGO1, or an AGO1-interacting protein, is a major client of CyP40 and that miR156 and its targets play a central role in the regulation of vegetative phase change in Arabidopsis.
机译：SQUINT（SQN）的功能丧失突变，编码cydophilin 40（CyP40）的拟南芥直系同源物，导致成年植物性状过早表达，心皮数增加，并在花序中产生异常的花距。在这里，我们显示sqn的营养表型可归因于转录因子SPL家族中miR156调节成员的表达升高，并提供证据表明该缺陷是ARGONAUTE1（AGO1）活性降低的结果。后一个结论的支持是由AGO1的亚同型表型和SQN无效等位基因之间的表型相似性以及sqn与这些等位基因之间的遗传相互作用提供的。我们的研究结果表明，AGO1或AGO1相互作用蛋白是CyP40的主要客户，而miR156及其靶标在拟南芥营养相变的调控中起着核心作用。

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