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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Transcriptional Neoteny In The Human Brain
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Transcriptional Neoteny In The Human Brain

机译：人脑中的转录新陈代谢

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摘要

In development, timing is of the utmost importance, and the timing of developmental processes often changes as organisms evolve. In human evolution, developmental retardation, or neoteny, has been proposed as a possible mechanism that contributed to the rise of many human-specific features, including an increase in brain size and the emergence of human-specific cognitive traits. We analyzed mRNA expression in the prefrontal cortex of humans, chimpanzees, and rhesus macaques to determine whether human-specific neotenic changes are present at the gene expression level. We show that the brain transcriptome is dramatically remodeled during postnatal development and that developmental changes in the human brain are indeed delayed relative to other primates. This delay is not uniform across the human transcriptome but affects a specific subset of genes that play a potential role in neural development.
机译：在发育中，时间是最重要的，而发育过程的时间通常会随着生物的进化而变化。在人类进化中，发育迟缓或新生儿衰弱被认为是可能导致许多人类特异性特征上升的可能机制，包括脑尺寸的增加和人类特异性认知特征的出现。我们分析了人类，黑猩猩和恒河猴的前额叶皮层中的mRNA表达，以确定在基因表达水平上是否存在人类特异性新肾上腺皮质改变。我们表明，脑转录组在产后发育过程中得到了显着重塑，并且人脑的发育变化确实相对于其他灵长类动物被延迟了。这种延迟在整个人类转录组中并不统一，但会影响在神经发育中发挥潜在作用的特定基因子集。

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  • 作者

    Mehmet Somel; Henriette Franz; Zheng Yan; Anna Lorenc; Song Guo; Thomas Giger; Janet Kelso; Birgit Nickel; Michael Dannemann; Sabine Bahn; Maree J. Webster; Cynthia S. Weickert; Michael Lachmann; Svante Paeaebo; Philipp Khaitovich;

  • 作者单位

    Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue Yang Road, Shanghai 200031, China Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, D-04103 Leipzig, Germany;

    Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, D-04103 Leipzig, Germany Max Planck Institute for Biophysical Chemistry, Am Fassberg 11, D-37077 Goettingen, Germany;

    Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue Yang Road, Shanghai 200031, China;

    Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, D-04103 Leipzig, Germany;

    Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue Yang Road, Shanghai 200031, China;

    Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, D-04103 Leipzig, Germany;

    Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, D-04103 Leipzig, Germany;

    Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, D-04103 Leipzig, Germany;

    Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, D-04103 Leipzig, Germany;

    Institute of Biotechnology, University of Cambridge, Cambridge CB2 1TN, United Kingdom;

    Stanley Medical Research Institute, 9800 Medical Center Drive, Rockville, MD 20850;

    Macquarie Group Foundation Chair of Schizophrenia Research, Schizophrenia Research Institute, Prince of Wales Medical Research Institute, University of New South Wales, Sydney, NSW 2052, Australia;

    Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, D-04103 Leipzig, Germany;

    Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, D-04103 Leipzig, Germany;

    Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue Yang Road, Shanghai 200031, China Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, D-04103 Leipzig, Germany;

  • 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    human evolution; brain development; gene expression; heterochrony; chimpanzee;

    机译：人类进化;大脑发育;基因表达;异时性;黑猩猩;

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