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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Transgenic multivitamin corn through biofortification of endosperm with three vitamins representing three distinct metabolic pathways
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Transgenic multivitamin corn through biofortification of endosperm with three vitamins representing three distinct metabolic pathways

机译：通过胚乳与三种代表三种不同代谢途径的维生素的生物强化对转基因多种维生素玉米

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摘要

Vitamin deficiency affects up to 50% of the world's population, disproportionately impacting on developing countries where populations endure monotonous, cereal-rich diets. Transgenic plants offer an effective way to increase the vitamin content of staple crops, but thus far it has only been possible to enhance individual vitamins. We created elite inbred South African transgenic corn plants in which the levels of 3 vitamins were increased specifically in the endosperm through the simultaneous modification of 3 separate metabolic pathways. The transgenic kernels contained 169-fold the normal amount of β-carotene, 6-fold the normal amount of ascorbate, and double the normal amount of folate. Levels of engineered vitamins remained stable at least through to the T3 homozygous generation. This achievement, which vastly exceeds any realized thus far by conventional breeding alone, opens the way for the development of nutritionally complete cereals to benefit the world's poorest people.
机译：维生素缺乏症影响世界上多达50％的人口，对人口忍受单调，富含谷物饮食的发展中国家的影响尤其严重。转基因植物提供了增加主粮中维生素含量的有效方法，但到目前为止，仅增强单个维生素是可行的。我们创建了优良的近交南非转基因玉米植株，其中通过同时修饰3种独立的代谢途径，在胚乳中3种维生素的含量特别增加。转基因谷粒所含β-胡萝卜素含量是正常含量的169倍，抗坏血酸含量是正常含量的6倍，叶酸含量是正常含量的两倍。工程维生素的水平至少在T3纯合世代之前一直保持稳定。这一成就大大超过了迄今为止仅通过常规育种就已实现的成就，这为开发营养全面的谷物以造福世界上最贫困的人们开辟了道路。

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  • 作者

    Shaista Naqvi; Changfu Zhu; Gemma Farre; Koreen Ramessar; Ludovic Bassie; Juergen Breitenbach; Dario Perez Conesa; Gaspar Ros; Gerhard Sandmann; Teresa Capell; Paul Christou;

  • 作者单位

    Departament de Produccio Vegetal i Ciencia Forestal, Universitat de Lleida, 25198 Lleida, Spain;

    Departament de Produccio Vegetal i Ciencia Forestal, Universitat de Lleida, 25198 Lleida, Spain;

    Departament de Produccio Vegetal i Ciencia Forestal, Universitat de Lleida, 25198 Lleida, Spain;

    Departament de Produccio Vegetal i Ciencia Forestal, Universitat de Lleida, 25198 Lleida, Spain;

    Departament de Produccio Vegetal i Ciencia Forestal, Universitat de Lleida, 25198 Lleida, Spain;

    Biosynthesis Group, Molecular Biosciences, Johann Wolfgang Goethe Universitaet, D-60054 Frankfurt, Germany;

    Departamento de Technologia de Alimentos, Nutricion y Bromatologia, Facultad de Veterinaria, Universidad de Murcia, Campus de Espinardo, 30100 Murcia, Spain;

    Departamento de Technologia de Alimentos, Nutricion y Bromatologia, Facultad de Veterinaria, Universidad de Murcia, Campus de Espinardo, 30100 Murcia, Spain;

    Biosynthesis Group, Molecular Biosciences, Johann Wolfgang Goethe Universitaet, D-60054 Frankfurt, Germany;

    Departament de Produccio Vegetal i Ciencia Forestal, Universitat de Lleida, 25198 Lleida, Spain;

    Departament de Produccio Vegetal i Ciencia Forestal, Universitat de Lleida, 25198 Lleida, Spain Institucio Catalana de Recerca i Estudis Avancats, 08010 Barcelona, Spain;

  • 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    folic acid; metabolic engineering; transgenic maize; vitamin A fortification; vitamin C;

    机译：叶酸;代谢工程;转基因玉米维生素A强化维生素C;

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