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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Proximity of excitatory and inhibitory axon terminals adjacent to pyramidal cell bodies provides a putative basis for nonsynaptic interactions
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Proximity of excitatory and inhibitory axon terminals adjacent to pyramidal cell bodies provides a putative basis for nonsynaptic interactions

机译：与锥体细胞体相邻的兴奋性轴突末端和抑制性轴突末端的接近为非突触相互作用提供了假定的基础

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摘要

Although pyramidal cells are the main excitatory neurons in the cerebral cortex, it has recently been reported that they can evoke inhibitory postsynaptic currents in neighboring pyramidal neurons. These inhibitory effects were proposed to be mediated by putative axo-axonic excitatory synapses between the axon terminals of pyramidal cells and perisomatic inhibitory axon terminals [Ren M, Yoshimura Y, Takada N, Horibe S, Komatsu Y (2007) Science 316:758-761]. However, the existence of this type of axo-axonic synapse was not found using serial section electron microscopy. Instead, we observed that inhibitory axon terminals synapsing on pyramidal cell bodies were frequently apposed by terminals that established excitatory synapses with neighbouring dendrites. We propose that a spillover of glutamate from these excitatory synapses can activate the adjacent inhibitory axo-somatic terminals.
机译：尽管锥体细胞是大脑皮质中主要的兴奋性神经元，但最近有报道称它们可以在邻近的锥体神经元中引起抑制性突触后电流。这些抑制作用被认为是由锥体细胞的轴突末端和周围的抑制性轴突末端之间的假定的轴突-轴突兴奋性突触介导的[Ren M，Yoshimura Y，Takada N，Horibe S，Komatsu Y（2007）Science 316：758- 761]。但是，使用连续切片电子显微镜未发现这种类型的轴突突触突触的存在。取而代之的是，我们观察到在锥体细胞体上突触抑制性轴突末端经常被与周围树突建立兴奋性突触的末端并置。我们建议从这些兴奋性突触的谷氨酸溢出可以激活相邻的抑制性轴突体末端。

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