...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >His protects heme as it crosses the membrane
【24h】

His protects heme as it crosses the membrane

机译：他穿过血膜时保护血红素

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

From the multitude of proteins with bound prosthetic groups, metal clusters, or cofactors, the soluble e-type cytochromes were among the first to be characterized, probably because of their spectral visibility and unusual stability. The pathway for their biosyntheses, nevertheless, remains to be filled in as do the mechanistic details of holoprotcin formation. Historically, many assumed, perhaps naively, that the assembly of most metallo-or other cofactor-containing proteins occurred without catalysis, relying on spontaneity, and this ide; was reinforced by the facile in vitro formation of stable FeS clusters and uncatalyzcd in vitro reconstitution of metalloproteins like plastocyanins or ferredoxins from inorganic ions and apoproteins. Today, we appreciate that synthesis of a functional holoprotein is a biochemical pathway with multiple catalyzed steps that ensure selectivity and specificity.
机译：从具有结合的修复基团，金属簇或辅因子的多种蛋白质中，可溶的e型细胞色素是最早被表征的一种，可能是由于它们的光谱可见性和异常的稳定性。尽管如此，它们的生物合成途径以及万花青素形成机理的细节仍待填补。从历史上看，许多人以为是天真的，大多数含金属或其他辅因子的蛋白质的组装是在没有催化的情况下进行的，而这种反应依赖于自发性和这种观念。易形成稳定的FeS簇的体外形成，以及从无机离子和载脂蛋白中无性地体外重组金属蛋白（如质体蓝蛋白或铁氧还蛋白）而得到增强。今天，我们认识到功能性全蛋白的合成是一条生化途径，具有多个催化步骤，可确保选择性和特异性。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号