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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Biodegradable fluorescent polymers
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Biodegradable fluorescent polymers

机译：可生物降解的荧光聚合物

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摘要

Although fluorescent dyes and quantum dots are widely used in bench research, longer-term use of these reagents in vivo is made difficult by their toxicity. Fluorescent proteins, on the other hand, are nontoxic, but have low quantum yield and bleach easily. Jian Yang et al. introduce an alternative: aliphaticrnbiodegradable fluorescent polymers that can be crosslinked into membranes. The polymers may serve as scaffolds in tissue engineering and drug delivery, and permit in vivo monitoring of structure. The authors modified the fabrication process for polymers that they had previously developed by reacting citric acid with 1,8-octanediol. In the new process, an amino acid is introduced at the same time as the citric acid and joins the polymer as a side chain.
机译：尽管荧光染料和量子点已广泛用于实验室研究，但由于其毒性，很难在体内长期使用这些试剂。另一方面，荧光蛋白无毒，但量子产率低且容易漂白。简阳等。引入替代方法：可以交联成膜的脂族可生物降解的荧光聚合物。该聚合物可以在组织工程和药物递送中用作支架，并允许体内监测结构。作者修改了以前通过柠檬酸与1,8-辛二醇反应开发的聚合物的制备方法。在新工艺中，氨基酸与柠檬酸同时引入，并作为侧链连接聚合物。

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