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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Modeling the immune rheostat of macrophages in the lung in response to infection
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Modeling the immune rheostat of macrophages in the lung in response to infection

机译：对感染后肺中巨噬细胞的免疫变阻器建模

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摘要

In the lung, alternatively activated macrophages (AAM) form the first line of defense against microbiai infection. Due to the highly regulated nature of AAM, the lung can be considered as an immunosuppressive organ for respiratory pathogens. However, as infection progresses in the lung, another population of macrophages, known as classically activated macrophages (CAM) enters; these cells are typically activated by IFN-γ. CAM are far more effective than AAM in clearing the microbiai load, producing proinflammatory cytokines and antimicrobial defense mechanisms necessary to mount an adequate immune response. Here, we are concerned with determining the first time when the population of CAM becomes more dominant than the population of AAM. This proposed "switching time" is explored in the context of Mycobac-terium tuberculosis (MTb) infection. We have developed a mathematical model that describes the interactions among cells, bacteria, and cytokines involved in the activation of both AAM and CAM. The model, based on a system of differential equations, represents a useful tool to analyze strategies for reducing the switching time, and to generate hypotheses for experimental testing.
机译：在肺中，交替激活的巨噬细胞（AAM）形成了抵御微生物感染的第一道防线。由于AAM的高度调节性质，因此可以将肺视为呼吸道病原体的免疫抑制器官。但是，随着肺部感染的进展，另一群巨噬细胞被称为经典激活的巨噬细胞（CAM）进入。这些细胞通常被IFN-γ激活。 CAM比AAM在清除微生物负荷，产生促炎细胞因子和抗菌防御机制（进行适当的免疫反应）方面要有效得多。在这里，我们关注的是确定CAM群体首次变得比AAM群体更具统治力。在结核分枝杆菌（MTb）感染的背景下探讨了该建议的“转换时间”。我们已经开发了一个数学模型，描述了参与AAM和CAM激活的细胞，细菌和细胞因子之间的相互作用。该模型基于微分方程组，代表了一种有用的工具，可以分析减少切换时间的策略，并为实验测试生成假设。

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  • 作者

    Judy Day; Avner Friedman; Larry S. Schlesinger;

  • 作者单位

    Mathematical Biosciences Institute, Department of Internal Medicine, Division of Infectious Diseases, Ohio State University, Columbus, OH 43210;

    Mathematical Biosciences Institute, Department of Internal Medicine, Division of Infectious Diseases, Ohio State University, Columbus, OH 43210 Department of Mathematics, Department of Internal Medicine, Division of Infectious Diseases, Ohio State University, Columbus, OH 43210;

    Center for Microbial Interface Biology, Department of Internal Medicine, Division of Infectious Diseases, Ohio State University, Columbus, OH 43210;

  • 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    alternatively activated macrophages; lung innate immunity mycobacteria tuberculosis;

    机译：交替激活的巨噬细胞;肺先天免疫结核分枝杆菌;

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