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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Programmed loss of millions of base pairs from a vertebrate genome
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Programmed loss of millions of base pairs from a vertebrate genome

机译：计划从脊椎动物基因组中损失数百万个碱基对

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In general, the strict preservation of broad-scale structure is thought to be critical for maintaining the precisely tuned functionality of vertebrate genomes, although nearly all vertebrate species undergo a small number of programmed local rearrangements during development (e.g., remodeling of adaptive immune receptor loci). However, a limited number of metazoan species undergo much more extensive reorganizations as a normal feature of their development. Here, we show that the sea lamprey (Petromyzon marinus), a jawless vertebrate, undergoes a dramatic remodeling of its genome, resulting in the elimination of hundreds of millions of base pairs (and at least one transcribed locus) from many somatic cell lineages during embryonic development. These studies reveal the highly dynamic nature of the lamprey genome and provide the first example of broad-scale programmed rearrangement of a definitively vertebrate genome. Understanding the mechanisms by which this vertebrate species regulates such extensive remodeling of its genome will provide invaluable insight into factors that can promote stability and change in vertebrate genomes.
机译：通常，严格保留大规模结构对于维持脊椎动物基因组的精确调节功能至关重要，尽管几乎所有脊椎动物在发育过程中都会经历少量的程序化局部重排（例如，适应性免疫受体基因座的重塑） ）。然而，有限的后生动物物种经历了更为广泛的重组，这是其发展的正常特征。在这里，我们显示无颚脊椎动物海七lamp鳗（Petromyzon marinus）经历了其基因组的戏剧性重塑，从而导致在此过程中许多体细胞谱系中消除了数亿个碱基对（以及至少一个转录的基因座）胚胎发育。这些研究揭示了七lamp鳗基因组的高度动态特性，并提供了脊椎动物脊椎动物基因组大规模程序化重排的第一个例子。了解该脊椎动物物种调节其基因组如此广泛重塑的机制将提供对可以促进脊椎动物基因组稳定性和变化的因素的宝贵见解。

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