...
首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Cognitive fitness of cost-efficient brain functional networks
【24h】

Cognitive fitness of cost-efficient brain functional networks

机译:具有成本效益的大脑功能网络的认知适应性

获取原文
获取原文并翻译 | 示例
           

摘要

The human brain's capacity for cognitive function is thought to depend on coordinated activity in sparsely connected, complex networks organized over many scales of space and time. Recent work has demonstrated that human brain networks constructed from neuroimaging data have economical small-world properties that confer high efficiency of information processing at relatively low connection cost. However, it has been unclear how the architecture of complex brain networks functioning at different frequencies can be related to behavioral performance on cognitive tasks. Here, we show that impaired accuracy of working memory could be related to suboptimal cost efficiency of brain functional networks operating in the classical β frequency band, 15-30 Hz. We analyzed brain functional networks derived from magnetoencephalography data recorded during working-memory task performance in 29 healthy volunteers and 28 people with schizophrenia. Networks functioning at higher frequencies had greater global cost efficiency than low-frequency networks in both groups. Superior task performance was positively correlated with global cost efficiency of the β-band network and specifically with cost efficiency of nodes in left lateral parietal and frontal areas. These results are consistent with biophysical models highlighting the importance of β-band oscillations for long-distance functional connections in brain networks and with pathophysiological models of schizophrenia as a dysconnection syndrome. More generally, they echo the saying that "less is more": The information processing performance of a network can be enhanced by a sparse or low-cost configuration with disproportionately high efficiency.
机译:人们认为,人脑的认知功能能力取决于在许多时空尺度上组织的,稀疏连接的复杂网络中的协调活动。最近的工作表明,由神经影像数据构建的人脑网络具有经济的小世界特性,可在相对较低的连接成本下实现信息处理的高效率。然而,目前尚不清楚以不同频率运行的复杂脑网络的架构如何与认知任务的行为表现相关。在这里,我们表明工作记忆的准确性受损可能与在经典β频带(15-30 Hz)中运行的大脑功能网络的次优成本效率有关。我们分析了在29名健康志愿者和28名精神分裂症患者工作记忆任务执行期间记录的脑磁图数据得出的大脑功能网络。在两组中,以较高频率运行的网络比具有低频网络的全局成本效率更高。出色的任务性能与β波段网络的整体成本效率呈正相关,特别是与左侧顶壁和额叶区域中节点的成本效率呈正相关。这些结果与强调β波段振荡对脑网络中长距离功能连接的重要性的生物物理模型以及作为分离障碍综合征的精神分裂症的病理生理模型相一致。更普遍地说,他们赞同“少即是多”的说法:网络的信息处理性能可以通过稀疏或低成本的配置以不成比例的高效率来增强。

著录项

  • 来源
  • 作者单位

    Genes Cognition and Psychosis Program, Clinical Brain Disorders Branch, National Institutes of Health, Bethesda, MD 20892 Behavioural and Clinical Neurosciences Institute, Department of Psychiatry, University of Cambridge, Cambridge CB2 0QQ, United Kingdom Biological Soft Systems Sector, Department of Physics, University of Cambridge, Cambridge CB2 1TN, United Kingdom;

    Behavioural and Clinical Neurosciences Institute, Department of Psychiatry, University of Cambridge, Cambridge CB2 0QQ, United Kingdom Clinical Unit Cambridge, GlaxoSmithKline, Addenbrooke's Hospital, Cambridge CB2 0QQ, United Kingdom;

    Central Institute of Mental Health, 68072 Mannheim, Germany;

    Genes Cognition and Psychosis Program, Clinical Brain Disorders Branch, National Institutes of Health, Bethesda, MD 20892;

    Genes Cognition and Psychosis Program, Clinical Brain Disorders Branch, National Institutes of Health, Bethesda, MD 20892;

    Magnetoencephalography Core Facility, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892;

  • 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    efficiency; graph theory; schizophrenia; working memory; magnetoencephalography;

    机译:效率;图论精神分裂症;工作记忆;脑磁图;

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号