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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Fully functional bioengineered tooth replacement as an organ replacement therapy
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Fully functional bioengineered tooth replacement as an organ replacement therapy

机译：全功能生物工程牙齿替代疗法作为器官替代疗法

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摘要

Current approaches to the development of regenerative therapies have been influenced by our understanding of embryonic development, stem cell biology, and tissue engineering technology. The ultimate goal of regenerative therapy is to develop fully functioning bioengineered organs which work in cooperation with surrounding tissues to replace organs that were lost or damaged as a result of disease, injury, or aging. Here, we report a successful fully functioning tooth replacement in an adult mouse achieved through the transplantation of bioengineered tooth germ into the alveolar bone in the lost tooth region. We propose this technology as a model for future organ replacement therapies. The bioengineered tooth, which was erupted and occluded, had the correct tooth structure, hardness of mineralized tissues for mastication, and response to noxious stimulations such as mechanical stress and pain in cooperation with other oral and maxillofacial tissues. This study represents a substantial advance and emphasizes the potential for bioengineered organ replacement in future regenerative therapies.
机译：我们对胚胎发育，干细胞生物学和组织工程技术的了解影响了再生疗法发展的当前方法。再生疗法的最终目标是开发功能全面的生物工程器官，该器官与周围组织协同工作，以替代因疾病，损伤或衰老而丢失或损坏的器官。在这里，我们报告了通过将生物工程化的牙胚移植到丢失的牙齿区域的牙槽骨中而在成年小鼠中成功完成的全功能牙齿替换。我们建议将该技术作为未来器官替代疗法的模型。经过生物工程处理的牙齿已萌出并被咬合，具有正确的牙齿结构，矿化组织的硬度，可进行咀嚼，并与其他口腔和颌面组织协作，对有害刺激（例如机械应力和疼痛）做出了响应。这项研究代表了重大进展，并强调了在未来的再生疗法中生物工程器官替代的潜力。

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  • 作者

    Etsuko lkeda; Ritsuko Morita; Kazuhisa Nakao; Kentaro lshida; Takashi Nakamura; Teruko Takano-Yamamoto; Miho Ogawa; Mitsumasa Mizuno; Shohei Kasugai; Takashi Tsuji;

  • 作者单位

    Department of Biological Science and Technology, Faculty of Industrial Science and Technology, Tokyo University of Science, Noda, Chiba 278-8510, Japan Organ Technologies Inc., Tokyo 101-0048, Japan;

    Department of Biological Science and Technology, Faculty of Industrial Science and Technology, Tokyo University of Science, Noda, Chiba 278-8510, Japan Research Institute for Science and Technology, Tokyo University of Science, Noda, Chiba 278-8510, Japan;

    Department of Biological Science and Technology, Faculty of Industrial Science and Technology, Tokyo University of Science, Noda, Chiba 278-8510, Japan Research Institute for Science and Technology, Tokyo University of Science, Noda, Chiba 278-8510, Japan;

    Department of Biological Science and Technology, Faculty of Industrial Science and Technology, Tokyo University of Science, Noda, Chiba 278-8510, Japan Research Institute for Science and Technology, Tokyo University of Science, Noda, Chiba 278-8510, Japan;

    Department of Biological Science and Technology, Faculty of Industrial Science and Technology, Tokyo University of Science, Noda, Chiba 278-8510, Japan Research Institute for Science and Technology, Tokyo University of Science, Noda, Chiba 278-8510, Japan;

    Division of Orthodontics and Dentofacial Orthopedics, Graduate School of Dentistry, Tohoku University, Sendai, Miyagi 980-8575, Japan;

    Organ Technologies Inc., Tokyo 101-0048, Japan;

    Department of Biological Science and Technology, Faculty of Industrial Science and Technology, Tokyo University of Science, Noda, Chiba 278-8510, Japan Research Institute for Science and Technology, Tokyo University of Science, Noda, Chiba 278-8510, Japan Division of Orthodontics and Dentofacial Orthopedics, Graduate School of Dentistry, Tohoku University, Sendai, Miyagi 980-8575, Japan;

    Oral and Maxillofacial Surgery, Department of Oral Restitution, Division of Oral Health Sciences, Graduate School, Tokyo Medical and Dental University, Tokyo 113-8510, Japan;

    Department of Biological Science and Technology, Faculty of Industrial Science and Technology, Tokyo University of Science, Noda, Chiba 278-8510, Japan Organ Technologies Inc., Tokyo 101-0048, Japan Research Institute for Science and Technology, Tokyo University of Science, Noda, Chiba 278-8510, Japan;

  • 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
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  • 关键词

    regenerative therapy; transplantation;

    机译：再生疗法;移植;

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