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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Organization of the autoantibody repertoire in healthy newborns and adults revealed by system level informatics of antigen microarray data
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Organization of the autoantibody repertoire in healthy newborns and adults revealed by system level informatics of antigen microarray data

机译：通过抗原微阵列数据的系统级信息揭示健康新生儿和成人体内自身抗体库的组织

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摘要

The immune system is essential to body defense and maintenance. Specific antibodies to foreign invaders function in body defense, and it has been suggested that autoantibodies binding to self molecules are important in body maintenance. Recently, the autoantibody repertoires in the bloods of healthy mothers and their newborns were studied using an antigen microarray containing hundreds of self molecules. It was found that the mothers expressed diverse repertoires for both IgG and IgM autoantibodies. Each newborn shares with its mother a similar repertoire of IgG antibodies, which cross the placental but its IgM repertoire is more similar to those of other newborns. Here, we took a system-level approach and analyzed the correlations between autoantibody reactivities of the previous data and extended the study to new data from newborns at birth and a week later, and from healthy young women. For the young women, we found modular organization of both IgG and IgM isotypes into antigen cliques-subgroups of highly correlated antigen reactivities. In contrast, the newborns were found to share a universal congenital IgM profile with no modular organization. Moreover, the IgG autoantibodies of the newborns manifested buds of the mothers' antigen cliques, but they were noticeably less structured. These findings suggest that the natural autoantibody repertoire of humans shows relatively little organization at birth, but, by young adulthood, it becomes sorted out into a modular organization of subgroups (cliques) of correlated antigens. These features revealed by antigen microarrays can be used to define personal states of autoantibody organizational motifs.
机译：免疫系统对于身体防御和维持至关重要。针对外来入侵者的特异性抗体在身体防御中起作用，并且已经表明与自身分子结合的自身抗体在身体维持中很重要。最近，使用包含数百个自身分子的抗原微阵列研究了健康母亲及其新生儿血液中的自身抗体库。发现母亲对IgG和IgM自身抗体均表达了不同的库。每个新生儿与其母亲共享相似的IgG抗体库，这些抗体跨胎盘，但其IgM库与其他新生儿更相似。在这里，我们采用了系统级的方法，分析了先前数据的自身抗体反应性之间的相关性，并将研究扩展至出生时和一周后的新生儿以及健康的年轻女性的新数据。对于年轻女性，我们发现IgG和IgM同种型的模块化组织成为高度相关的抗原反应性的抗原团-亚组。相比之下，发现新生儿具有通用的先天性IgM谱图，而没有模块化组织。此外，新生儿的IgG自身抗体表现出母亲的抗原团的芽，但结构明显较差。这些发现表明，人类的天然自身抗体库在出生时显示出相对较少的组织，但是，到成年后，它就被分类为相关抗原亚组（模块）的模块化组织。抗原微阵列揭示的这些特征可用于定义自身抗体组织基序的个人状态。

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    Asaf Madi; Inbal Hecht; Sharron Bransburg-Zabary; Yifat Merbl; Adi Pick; Merav Zucker-Toledano; Francisco J. Quintana; Alfred I. Tauber; Irun R. Cohen; Eshel Ben-Jacob;

  • 作者单位

    The Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel;

    The Sackler School of Physics and Astronomy, Tel Aviv University, Tel Aviv 69978, Israel The Center for Theoretical Biological Physics, University of California San Diego, La Jolla, CA 92093;

    The Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel The Sackler School of Physics and Astronomy, Tel Aviv University, Tel Aviv 69978, Israel;

    Department of Immunology, Weizmann Institute of Science, Rehovot 76100, Israel;

    The Sackler School of Physics and Astronomy, Tel Aviv University, Tel Aviv 69978, Israel;

    The Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel Pediatric Department, Dana Children's Hospital, Tel-Aviv Sourasky Medical Center, Tel-Aviv 64239, Israel;

    Department of Immunology, Weizmann Institute of Science, Rehovot 76100, Israel;

    Department of Medicine, School of Medicine, Boston University, Boston, MA 02118;

    Department of Immunology, Weizmann Institute of Science, Rehovot 76100, Israel;

    The Sackler School of Physics and Astronomy, Tel Aviv University, Tel Aviv 69978, Israel The Center for Theoretical Biological Physics, University of California San Diego, La Jolla, CA 92093;

  • 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
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  • 关键词

    immune development; immune holography; immune network network cliques;

    机译：免疫发展;免疫全息术免疫网络网络集团;

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