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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Endogenous nonneuronal modulators of synaptic transmission control cortical slow oscillations in vivo
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Endogenous nonneuronal modulators of synaptic transmission control cortical slow oscillations in vivo

机译：突触传递的内源性非神经调节剂控制体内皮质缓慢振荡。

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摘要

Gliotransmission, the release of molecules from astrocytes, regulates neuronal excitability and synaptic transmission in situ. Whether this process affects neuronal network activity in vivo is not known. Using a combination of astrocyte-specific molecular genetics, with in vivo electrophysiology and pharmacology, we determined that gliotransmission modulates cortical slow oscillations, a rhythm characterizing nonrapid eye movement sleep. Inhibition of gliotransmission by the expression of a dominant negative SNARE domain in astrocytes affected cortical slow oscillations, reducing the duration of neuronal depolarizations and causing prolonged hyperpolarizations. These network effects result from the astrocytic modulation of intracortical synaptic transmission at two sites: a hypofunction of postsynaptic NMDA receptors, and by reducing extracellular adenosine, a loss of tonic A1 receptor-mediated inhibition. These results demonstrate that rhythmic brain activity is generated by the coordinated action of the neuronal and glial networks.
机译：神经胶质传递，从星形胶质细胞释放的分子，调节神经元的兴奋性和突触传递的原位。该过程是否影响体内神经网络活动尚不清楚。使用星形胶质细胞特异性分子遗传学与体内电生理学和药理学相结合，我们确定神经胶质传递调节皮层慢振荡，这是快速眼动睡眠的特征性节律。星形胶质细胞中显性负性SNARE结构域的表达抑制胶质细胞传递影响皮质的缓慢振荡，减少神经元去极化的持续时间并导致长时间的超极化。这些网络效应是由两个位置的皮层内突触传递的星形细胞调节所引起的：突触后NMDA受体功能减退，以及通过减少细胞外腺苷，导致强直性A1受体介导的抑制作用丧失。这些结果表明，节律性大脑活动是由神经元和神经胶质网络的协同作用产生的。

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    Tommaso Fellin; Michael M. Halassa; Miho Terunuma; Francesca Succol; Hajime Takano; Marcos Frank; Stephen J. Moss; Philip G. Haydon;

  • 作者单位

    Silvio Conte Center for Integration at the Tripartite Synapse, Department of Neuroscience, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 Department of Neuroscience and Brain Technologies, Italian Institute of Technology, 16163 Genova, Italy;

    Silvio Conte Center for Integration at the Tripartite Synapse, Department of Neuroscience, University of Pennsylvania School of Medicine, Philadelphia, PA 19104;

    Silvio Conte Center for Integration at the Tripartite Synapse, Department of Neuroscience, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 Department of Neuroscience,Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111;

    Silvio Conte Center for Integration at the Tripartite Synapse, Department of Neuroscience, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 Department of Neuroscience and Brain Technologies, Italian Institute of Technology, 16163 Genova, Italy;

    Silvio Conte Center for Integration at the Tripartite Synapse, Department of Neuroscience, University of Pennsylvania School of Medicine, Philadelphia, PA 19104;

    Silvio Conte Center for Integration at the Tripartite Synapse, Department of Neuroscience, University of Pennsylvania School of Medicine, Philadelphia, PA 19104;

    Silvio Conte Center for Integration at the Tripartite Synapse, Department of Neuroscience, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 Department of Neuroscience,Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111;

    Silvio Conte Center for Integration at the Tripartite Synapse, Department of Neuroscience, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 Department of Neuroscience,Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111;

  • 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
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  • 关键词

    adenosine; astrocytes; gliotransmission; NMDA receptor;

    机译：腺苷星形胶质细胞胶质传输NMDA受体;

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