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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Differential distribution of endoplasmic reticulum controls metabotropic signaling and plasticity at hippocampal synapses
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Differential distribution of endoplasmic reticulum controls metabotropic signaling and plasticity at hippocampal synapses

机译：内质网的差异分布控制海马突触的代谢型信号传导和可塑性

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摘要

Synaptic plasticity is considered essential for learning and storage of new memories. Whether all synapses on a given neuron have the same ability to express long-term plasticity is not well understood. Synaptic microanatomy could affect the function of local signaling cascades and thus differentially regulate the potential for plasticity at individual synapses. Here, we investigate how the presence of endoplasmic reticulum (ER) in dendritic spines of CA1 pyramidal neurons affects postsynaptic signaling. We show that the ER is targeted selectively to large spines containing strong synapses. In ER-containing spines, we frequently observed synap-tically triggered calcium release events of very large amplitudes. Low-frequency stimulation of these spines induced a permanent depression of synaptic potency that was independent of NMDA receptor activation and specific to the stimulated synapses. In contrast, no functional changes were induced in the majority of spines lacking ER. Both calcium release events and long-term depression depended on the activation of metabotropic glutamate receptors and inositol trisphosphate receptors. In summary, spine microanatomy is a reliable indicator for the presence of specific signaling cascades that govern plasticity on a micrometer scale.
机译：突触可塑性被认为是学习和存储新记忆必不可少的。给定神经元上的所有突触是否都具有表达长期可塑性的相同能力尚不清楚。突触的微观解剖可能会影响局部信号传导级联的功能，从而差异性地调节各个突触的可塑性。在这里，我们调查内质网（ER）在CA1锥体神经元的树突棘中的存在如何影响突触后信号。我们表明，急诊室有针对性地针对包含强突触的大刺。在含有内质网的棘中，我们经常观察到突触触发的钙释放事件，幅度非常大。这些棘突的低频刺激导致突触能力的永久抑制，这种能力与NMDA受体激活无关，并且对刺激的突触具有特异性。相反，在大多数缺乏内质网的脊柱中没有诱导功能改变。钙释放事件和长期抑郁都取决于代谢型谷氨酸受体和肌醇三磷酸受体的激活。总之，脊柱显微解剖学是在微米级控制可塑性的特定信号级联的可靠指标。

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