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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Sparsification of neuronal activity in the visual cortex at eye-opening
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Sparsification of neuronal activity in the visual cortex at eye-opening

机译：睁大眼睛时视皮层神经元活动的稀疏性

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摘要

Eye-opening represents a turning point in the function of the visual cortex. Before eye-opening, the visual cortex is largely devoid of sensory inputs and neuronal activities are generated intrinsically. After eye-opening, the cortex starts to integrate visual information. Here we used in vivo two-photon calcium imaging to explore the developmental changes of the mouse visual cortex by analyzing the ongoing spontaneous activity. We found that before eye-opening, the activity of layer 2/3 neurons consists predominantly of slow wave oscillations. These waves were first detected at postnatal day 8 (P8). Their initial very low frequency (0.01 Hz) gradually increased during development to ≈ 0.5 Hz in adults. Before eye-opening, a large fraction of neurons (>75%) was active during each wave. One day after eye-opening, this dense mode of recruitment changed to a sparse mode with only 36% of active neurons per wave. This was followed by a progressive decrease during the following weeks, reaching 12% of active neurons per wave in adults. The possible role of visual experience for this process of sparsification was investigated by analyzing dark-reared mice. We found that sparsification also occurred in these mice, but that the switch from a dense to a sparse activity pattern was delayed by 3-4 days as compared with normally-reared mice. These results reveal a modulatory contribution of visual experience during the first days after eye-opening, but an overall dominating role of intrinsic factors. We propose that the transformation in network activity from dense to sparse is a prerequisite for the changed cortical function at eye-opening.
机译：睁大眼睛代表了视觉皮层功能的转折点。在睁大眼睛之前，视觉皮层很大程度上没有感觉输入，并且内在地产生神经元活动。睁大眼睛后，皮质开始整合视觉信息。在这里，我们通过分析正在进行的自发活动，使用体内双光子钙成像来探索小鼠视觉皮层的发育变化。我们发现，在睁大眼睛之前，第2/3层神经元的活动主要由慢波振荡组成。这些波是在出生后第8天（P8）首次检测到的。他们的最初非常低的频率（0.01 Hz）在发育过程中逐渐增加到成人的≈0.5 Hz。在睁大眼睛之前，每个波中都有很大一部分神经元（> 75％）处于活动状态。睁开眼睛后的一天，这种密集的募集模式变为稀疏模式，每个波仅激活神经​​元的36％。随后在接下来的几周内逐渐减少，成人每波活动神经元达到12％。通过分析深色饲养的小鼠，研究了视觉体验在此稀疏化过程中的可能作用。我们发现稀疏性也发生在这些小鼠中，但是与正常饲养的小鼠相比，从密集活动模式向稀疏活动模式的转换延迟了3-4天。这些结果揭示了在睁开眼睛后的第一天视觉体验的调节作用，但内在因素总体上起着主导作用。我们提出，网络活动从密集到稀疏的转变是睁大眼睛后改变皮质功能的前提。

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    Nathalie L. Rochefort; Olga Garaschuk; Ruxandra-Iulia Milos; Madoka Narushima; Nima Marandi; Bruno Pichler; Yury Kovalchuk; Arthur Konnerth;

  • 作者单位

    Center for Integrated Protein Science and Institute of Neuroscience, Technical University Munich, Biedersteinerstrasse 29, 80802 Munich, Germany;

    Center for Integrated Protein Science and Institute of Neuroscience, Technical University Munich, Biedersteinerstrasse 29, 80802 Munich, Germany;

    Center for Integrated Protein Science and Institute of Neuroscience, Technical University Munich, Biedersteinerstrasse 29, 80802 Munich, Germany;

    Center for Integrated Protein Science and Institute of Neuroscience, Technical University Munich, Biedersteinerstrasse 29, 80802 Munich, Germany;

    Center for Integrated Protein Science and Institute of Neuroscience, Technical University Munich, Biedersteinerstrasse 29, 80802 Munich, Germany;

    Center for Integrated Protein Science and Institute of Neuroscience, Technical University Munich, Biedersteinerstrasse 29, 80802 Munich, Germany;

    Center for Integrated Protein Science and Institute of Neuroscience, Technical University Munich, Biedersteinerstrasse 29, 80802 Munich, Germany;

    Center for Integrated Protein Science and Institute of Neuroscience, Technical University Munich, Biedersteinerstrasse 29, 80802 Munich, Germany;

  • 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
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  • 关键词

    calcium waves; cortical development; mouse; two-photon;

    机译：钙波;皮质发育;老鼠;两光子;

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