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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >The p53 target Wig-1 regulates p53 mRNA stability through an AU-rich element
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The p53 target Wig-1 regulates p53 mRNA stability through an AU-rich element

机译：p53靶标Wig-1通过富含AU的元件调节p53 mRNA的稳定性

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摘要

The p53 target gene Wig-1 encodes a double-stranded-RNA-bind-ing zinc finger protein. We show here that Wig-1 binds to p53 mRNA and stabilizes it through an AU-rich element (ARE) in the 3' UTR of the p53 mRNA. This effect is mirrored by enhanced p53 protein levels in both unstressed cells and cells exposed to p53-activating stress agents. Thus, the p53 target Wig-1 is a previously undescribed ARE-regulating protein that acts as a positive feedback regulator of p53, with implications both for the steady-state levels of p53 and for the p53 stress response. Our data reveal a previously undescribed link between the tumor suppressor p53 and posttranscriptional gene regulation via AREs in mRNA.
机译：p53靶基因Wig-1编码与RNA结合的双链锌指蛋白。我们在这里显示Wig-1与p53 mRNA结合并通过p53 mRNA 3'UTR中富含AU的元件（ARE）使其稳定。在未受压力的细胞和暴露于p53活化应激剂的细胞中，p53蛋白水平的提高反映了这一效应。因此，p53靶标Wig-1是一种先前未描述的ARE调节蛋白，可作为p53的正反馈调节剂，对p53的稳态水平和p53应激反应都有影响。我们的数据揭示了抑癌基因p53和转录后基因通过mRNA中的ARE调控之间的联系。

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    Anna Vilborg; Jacob A. Glahder; Margareta T. Wilhelm; Cinzia Bersani; Martin Corcoran; Salah Mahmoudi; Maiken Rosenstierne; Dan Grander; Marianne Farnebo; Bodil Norrild; Klas G. Wiman;

  • 作者单位

    Department of Oncology-Pathology, Cancer Center Karolinska, Karolinska Institute, SE-171 76 Stockholm, Sweden;

    Institute of Cellular and Molecular Medicine, Panum Institute, University of Copenhagen, DK-2100 Copenhagen N, Denmark;

    Department of Oncology-Pathology, Cancer Center Karolinska, Karolinska Institute, SE-171 76 Stockholm, Sweden Karolinska Institute, MTC, SE-171 77 Stockholm, Sweden;

    Department of Oncology-Pathology, Cancer Center Karolinska, Karolinska Institute, SE-171 76 Stockholm, Sweden;

    Department of Oncology-Pathology, Cancer Center Karolinska, Karolinska Institute, SE-171 76 Stockholm, Sweden;

    Department of Oncology-Pathology, Cancer Center Karolinska, Karolinska Institute, SE-171 76 Stockholm, Sweden;

    lnstitute of Cellular and Molecular Medicine, Panum Institute, University of Copenhagen, DK-2100 Copenhagen N, Denmark;

    Department of Oncology-Pathology, Cancer Center Karolinska, Karolinska Institute, SE-171 76 Stockholm, Sweden;

    Department of Oncology-Pathology, Cancer Center Karolinska, Karolinska Institute, SE-171 76 Stockholm, Sweden;

    lnstitute of Cellular and Molecular Medicine, Panum Institute, University of Copenhagen, DK-2100 Copenhagen N, Denmark;

    Department of Oncology-Pathology, Cancer Center Karolinska, Karolinska Institute, SE-171 76 Stockholm, Sweden;

  • 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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