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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Mechanochemical model for myosin V
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Mechanochemical model for myosin V

机译：肌球蛋白V的力学化学模型

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摘要

A rigorous numerical test of a hypothetical mechanism of a molecular motor should model explicitly the diffusive motion of the motor's degrees of freedom as well as the transition rates between the motor's chemical states. We present such a Brownian dynamics, mechanochemcial model of the coarse-grain structure of the dimeric, linear motor myosin V. Compared with run-length data, our model provides strong support for a proposed strain-controlled gating mechanism that enhances processivity. We demonstrate that the diffusion rate of a detached motor head during motor stepping is self-consistent with known kinetic rate constants and can explain the motor's key performance features, such as speed and stall force. We present illustrative and realistic animations of motor stepping in the presence of thermal noise. The quantitative success and illustrative power of this type of model suggest that it will be useful in testing our understanding of a range of biological and synthetic motors.
机译：分子电动机的假设机制的严格数值测试应明确地模拟电动机自由度的扩散运动以及电动机化学状态之间的跃迁速率。我们提出了这种二聚体线性马达肌球蛋白V的粗粒结构的布朗动力学力学化学模型。与游程数据相比，我们的模型为拟议的应变控制选通机制提供了有力的支持，该机制提高了生产率。我们证明了电机步进过程中分离的电机头的扩散速率与已知的动力学速率常数是自洽的，并且可以解释电机的关键性能特征，例如速度和失速力。我们提出了在存在热噪声的情况下电机步进的说明性和逼真的动画。这种类型的模型的定量成功和说明能力表明，它将有助于测试我们对一系列生物和合成发动机的理解。

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  • 作者

    Erin M. Craig; Heiner Linke;

  • 作者单位

    Materials Science Institute and Department of Physics, University of Oregon, Eugene, OR 97403 Department of Mathmatics, University of California at Davis, Davis, CA 95616;

    Materials Science Institute and Department of Physics, University of Oregon, Eugene, OR 97403 Nanometer Consortium and Division of Solid State Physics, Lund University, Box 118, S-22100 Lund, Sweden;

  • 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    brownian dynamics; molecular motor; strain-dependent gating;

    机译：布朗动力学分子马达应变依赖性门控;

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