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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Gray and white matter changes associated with tool-use learning in macaque monkeys
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Gray and white matter changes associated with tool-use learning in macaque monkeys

机译：与猕猴工具使用学习相关的灰白物质变化

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摘要

We used noninvasive MRI and voxel-based morphometry (VBM) to detect changes in brain structure in three adult Japanese macaques trained to use a rake to retrieve food rewards. Monkeys, who were naive to any previous tool use, were scanned repeatedly in a 4-T scanner over 6 weeks, comprising 2 weeks of habituation followed by 2 weeks of intensive daily training and a 2-week posttraining period. VBM analysis revealed significant increases in gray matter with rake performance across the three monkeys. The effects were most significant (P < 0.05 corrected for multiple comparisons across the whole brain) in the right superior temporal sulcus, right second somatosen-sory area, and right intraparietal sulcus, with less significant effects (P < 0.001 uncorrected) in these same regions of the left hemisphere. Bilateral increases were also observed in the white matter of the cerebellar hemisphere in lobule 5. In two of the monkeys who exhibited rapid learning of the rake task, gray matter volume in peak voxels increased by up to 17% during the intensive training period; the earliest changes were seen after 1 week of intensive training, and they generally peaked when performance on the task plateaued. In the third monkey, who was slower to learn the task, peak voxels showed no systematic changes. Thus, VBM can detect significant brain changes in individual trained monkeys exposed to tool-use training for the first time. This approach could open up a means of investigating the underlying neurobiology of motor learning and other higher brain functions in individual animals.
机译：我们使用无创MRI和基于体素的形态计量学（VBM）来检测三名成年猕猴的大脑结构变化，这些猕猴经过训练可以使用耙子来获取食物奖励。不熟悉任何先前工具使用的猴子，在4-T扫描仪中进行了6周的反复扫描，包括适应2周，然后进行2周的强化日常训练和2周的训练后时间。 VBM分析显示，三只猴子的ra耙表现使灰质显着增加。在右上颞沟，右第二躯体感觉区和右顶壁沟中，效果最为显着（P <0.05，经全脑多次比较校正），而在这些相​​同方面，效果较差（P <0.001，未校正）。左半球区域。在小叶5小脑半球的白质中也观察到双侧增加。在快速学习耙任务的两只猴子中，在强化训练期间，高峰体素中的灰质体积增加了高达17％。最早的变化是经过1周的强化训练后才能看到的，并且通常在任务表现稳定时达到顶峰。在学习速度较慢的第三只猴子中，高峰体素没有显示出系统的变化。因此，VBM可以在首次接受工具使用训练的个体训练猴子中检测到明显的大脑变化。这种方法可以为研究动物个体的运动学习和其他高级脑功能的神经生物学方法提供一种手段。

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    M. M. Quallo; C. J. Price; K. Ueno; T. Asamizuya; K. Cheng; R. N. Lemon; A. lriki;

  • 作者单位

    Laboratory for Symbolic Cognitive Development RIKEN Brain Science Institute, 2-1 Hirosawa, Wako-shi, Saitama 351-0198, Japan Sobell Department of Motor Neuroscience and Movement Disorders, University College London Institute of Neurology, London WC1N 3BG, United Kingdom;

    Wellcome Trust Centre for Neuroimaging, University College London Institute of Neurology, London WC1N 3BG, United Kingdom;

    fMRI Support Unit RIKEN Brain Science Institute, 2-1 Hirosawa, Wako-shi, Saitama 351-0198, Japan;

    fMRI Support Unit RIKEN Brain Science Institute, 2-1 Hirosawa, Wako-shi, Saitama 351-0198, Japan;

    fMRI Support Unit RIKEN Brain Science Institute, 2-1 Hirosawa, Wako-shi, Saitama 351-0198, Japan Laboratory for Cognitive Brain Mapping, RIKEN Brain Science Institute, 2-1 Hirosawa, Wako-shi, Saitama 351-0198, Japan;

    Laboratory for Symbolic Cognitive Development RIKEN Brain Science Institute, 2-1 Hirosawa, Wako-shi, Saitama 351-0198, Japan Sobell Department of Motor Neuroscience and Movement Disorders, University College London Institute of Neurology, London WC1N 3BG, United Kingdom;

    Laboratory for Symbolic Cognitive Development RIKEN Brain Science Institute, 2-1 Hirosawa, Wako-shi, Saitama 351-0198, Japan Sobell Department of Motor Neuroscience and Movement Disorders, University College London Institute of Neurology, London WC1N 3BG, United Kingdom;

  • 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
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  • 关键词

    intraparietal sulcus; second somatosensory area; superior temporal sulcus; voxel-based morphometry;

    机译：顶内沟;第二体感区颞上沟;基于体素的形态;

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