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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Destruction of spirochete Borrelia burgdorferi round-body propagules (RBs) by the antibiotic Tigecycline
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Destruction of spirochete Borrelia burgdorferi round-body propagules (RBs) by the antibiotic Tigecycline

机译：抗生素Tigecycline破坏螺旋体疏螺旋体伯氏疏螺旋体圆形繁殖体（RBs）

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摘要

Persistence of tissue spirochetes of Borrelia burgdorferi as helices and round bodies (RBs) explains many erythema-Lyme disease symptoms. Spirochete RBs (reproductive propagules also called coccoid bodies, globular bodies, spherical bodies, granules, cysts, L-forms, sphaeroplasts, or vesicles) are induced by environmental conditions unfavorable for growth. Viable, they grow, move and reversibly convert into motile helices. Reversible pleiomorphy was recorded in at least six spirochete genera (>12 species). Penicillin solution is one unfavorable condition that induces RBs. This antibiotic that inhibits bacterial cell wall synthesis cures neither the second "Great Imitator" (Lyme borreliosis) nor the first: syphilis. Molecular-microscopic techniques, in principle, can detect in animals (insects, ticks, and mammals, including patients) helices and RBs of live spirochetes. Genome sequences of B. burgdorferi and Treponema pallidum spirochetes show absence of >75% of genes in comparison with their free-living relatives. Irreversible integration of spirochetes at behavioral, metabolic, gene product and genetic levels into animal tissue has been documented. Irreversible integration of spirochetes may severely impair immunological response such that they persist undetected in tissue. We report in vitro inhibition and destruction of B. burgdorferi (helices, RBs = "cysts") by the antibiotic Tigecycline (TG; Wyeth), a glycylcycline protein-synthesis inhibitor (of both 30S and 70S ribosome sub-units). Studies of the pleiomorphic life history stages in response to TG of both B. burgdorferi and Treponema pallidum in vivo and in vitro are strongly encouraged.
机译：伯氏疏螺旋体的螺旋体和螺旋体（RB）持续存在解释了许多红斑-莱姆病症状。 Spirochete RBs（生殖繁殖体，也称为球状体，球状体，球形体，颗粒，囊肿，L型，球形塑料或囊泡）是由不利于生长的环境条件诱导的。它们有生命力，可以生长，移动并可逆地转化为能动的螺旋。在至少六个螺旋体属（> 12种）中记录了可逆的多形性。青霉素溶液是一种导致RBs的不利条件。这种抑制细菌细胞壁合成的抗生素既不能治愈第二种“大模仿者”（Lyme borreliosis），也不能治愈第一种：梅毒。原则上，分子显微镜技术可以检测动物（昆虫、,和哺乳动物，包括患者）的活螺旋体的螺旋和RB。伯氏疏螺旋体和螺旋体梅毒螺旋体的基因组序列与其自由生活的亲戚相比，缺少超过75％的基因。螺旋体在行为，代谢，基因产物和遗传水平上不可逆地整合到动物组织中的现象已有记录。螺旋体的不可逆整合可能会严重损害免疫反应，以至于它们在组织中未被发现持续存在。我们报告了抗生素Tigecycline（TG; Wyeth），一种甘氨酰环蛋白合成抑制剂（30S和70S核糖体亚基）在体外对B. burgdorferi（螺旋体，RBs =“囊肿”）的抑制和破坏。强烈鼓励在体内和体外研究B. burgdorferi和梅毒螺旋体对TG响应的多形生命历史阶段。

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