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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Stability of muscle synergies for voluntary actions after cortical stroke in humans
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Stability of muscle synergies for voluntary actions after cortical stroke in humans

机译：人类皮质中风后自愿行动的肌肉协同作用的稳定性

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摘要

Production of voluntary movements relies critically on the functional integration of several motor cortical areas, such as the primary motor cortex, and the spinal circuitries. Surprisingly, after almost 40 years of research, how the motor cortices specify descending neural signals destined for the downstream interneu-rons and motoneurons has remained elusive. In light of the many recent experimental demonstrations that the motor system may coordinate muscle activations through a linear combination of muscle synergies, we hypothesize that the motor cortices may function to select and activate fixed muscle synergies specified by the spinal or brainstem networks. To test this hypothesis, we recorded electromyograms (EMGs) from 12-16 upper arm and shoulder muscles from both the unaffected and the stroke-affected arms of stroke patients having moderate-to-severe unilateral isch-emic lesions in the frontal motor cortical areas. Analyses of EMGs using a nonnegative matrix factorization algorithm revealed that in seven of eight patients the muscular compositions of the synergies for both the unaffected and the affected arms were strikingly similar to each other despite differences in motor performance between the arms, and differences in cerebral lesion sizes and locations between patients. This robustness of muscle synergies that we observed supports the notion that descending cortical signals represent neuronal drives that select, activate, and flexibly combine muscle synergies specified by networks in the spinal cord and/or brainstem. Our conclusion also suggests an approach to stroke rehabilitation by focusing on those synergies with altered activations after stroke.
机译：自愿运动的产生主要取决于几个运动皮层区域的功能整合，例如初级运动皮层和脊椎回路。令人惊讶的是，经过近40年的研究，运动皮层如何指定发往下游中间神经元和运动神经元的递减神经信号仍然难以捉摸。鉴于最近的许多实验证明，运动系统可以通过肌肉协同作用的线性组合来协调肌肉激活，我们假设运动皮层可以起到选择和激活由脊柱或脑干网络指定的固定肌肉协同作用的作用。为了验证这一假设，我们记录了额叶运动皮层区域中度至重度单侧缺血性脑卒中患者未受影响和中风影响的手臂的12-16只上臂和肩部肌肉的肌电图（EMG） 。使用非负矩阵分解算法对EMG进行的分析显示，在八名患者中的七名患者中，尽管手臂之间的运动表现不同以及脑部病变有所不同，但未受影响的手臂和受影响的手臂的协同增效的肌肉成分却非常相似。患者之间的大小和位置。我们观察到的这种肌肉协同作用的鲁棒性支持以下观点：皮质信号下降代表神经元驱动器，该神经元驱动器选择，激活并灵活地组合由脊髓和/或脑干中的网络指定的肌肉协同作用。我们的结论还提出了一种针对卒中康复的方法，其重点在于卒中后激活改变的协同作用。

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    Vincent C. K. Cheung; Lamberto Piron; Michela Agostini; Stefano Silvoni; Andrea Turolla; Emilio Bizzi;

  • 作者单位

    McGovem Institute for Brain Research, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139;

    Istituto di Ricovero e Cura a Carattere Scientifico Ospedale San Camillo, Via Alberoni 70, 30126 Lido di Venezia, Italy;

    Istituto di Ricovero e Cura a Carattere Scientifico Ospedale San Camillo, Via Alberoni 70, 30126 Lido di Venezia, Italy;

    Istituto di Ricovero e Cura a Carattere Scientifico Ospedale San Camillo, Via Alberoni 70, 30126 Lido di Venezia, Italy;

    Istituto di Ricovero e Cura a Carattere Scientifico Ospedale San Camillo, Via Alberoni 70, 30126 Lido di Venezia, Italy;

    McGovem Institute for Brain Research, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139;

  • 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
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  • 关键词

    motor control; motor modules; neurorehabilitation; motor primitives; electromyography;

    机译：电机控制;电机模块;神经康复;运动原语肌电图;

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