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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Host structural carbohydrate induces vector transmission of a bacterial plant pathogen
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Host structural carbohydrate induces vector transmission of a bacterial plant pathogen

机译：宿主结构性碳水化合物诱导细菌植物病原体的载体传播

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摘要

Many insect-borne pathogens have complex life histories because they must colonize both hosts and vectors for successful dissemination. In addition, the transition from host to vector environments may require changes in gene expression before the pathogen's departure from the host. Xylella fastidiosa is a xylem-limited plant-pathogenic bacterium transmitted by leafhopper vectors that causes diseases in a number of economically important plants. We hypothesized that factors of host origin, such as plant structural poiysaccharides, are important in regulating X. fastidiosa gene expression and mediating vector transmission of this pathogen. The addition of pectin and glucan to a simple defined medium resulted in dramatic changes in X. fastidiosa's phenotype and gene-expression profile. Cells grown in the presence of pectin became more adhesive than in other media tested. In addition, the presence of pectin and glucan in media resulted in significant changes in the expression of several genes previously identified as important for X. fastidiosa's pathogenicity in plants. Furthermore, vector transmission of X. fastidiosa was induced in the presence of both poiysaccharides. Our data show that host structural poiysaccharides mediate gene regulation in X. fastidiosa. which results in phenotypk changes required for vector transmission. A better understanding of how vector-borne pathogens transition from host to vector, and vice versa, may lead to previously undiscovered disease-control strategies.
机译：许多昆虫传播的病原体具有复杂的生命史，因为它们必须在寄主和载体上定居，才能成功传播。另外，从宿主到载体环境的转变可能需要在病原体离开宿主之前改变基因表达。枯草杆菌是由叶蝉载体传播的木质部受限的植物致病细菌，在许多具有经济意义的植物中引起疾病​​。我们假设宿主起源的因子，例如植物结构多糖，在调节X. fastidiosa基因表达和介导该病原体的载体传递中很重要。在简单定义的培养基中添加果胶和葡聚糖会导致法氏假单胞菌的表型和基因表达谱发生显着变化。在果胶存在下生长的细胞比在其他测试的培养基中更具粘附性。另外，果胶和葡聚糖在培养基中的存在导致先前鉴定为对剑孢假单胞菌的植物致病性重要的几个基因的表达发生显着变化。此外，在两种多糖均存在的情况下，诱导了耐腐木霉的载体传播。我们的数据显示宿主结构多糖介导了X. fastidiosa中的基因调控。这导致载体传输所需的表型改变。更好地了解媒介传播的病原体如何从宿主转变为媒介，反之亦然，可能会导致以前未发现的疾病控制策略。

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