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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Differences in human and chimpanzee gene expression patterns define an evolving network of transcription factors in brain
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Differences in human and chimpanzee gene expression patterns define an evolving network of transcription factors in brain

机译：人类和黑猩猩基因表达模式的差异定义了大脑中转录因子的进化网络

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摘要

Humans differ from other primates by marked differences in cognitive abilities and a significantly larger brain. These differences correlate with metabolic changes, as evidenced by the relative up-regulation of energy-related genes and metabolites in human brain. While the mechanisms underlying these evolutionary changes have not been elucidated, altered activities of key transcription factors (TFs) could play a pivotal role. To assess this possibility, we analyzed microarray data from five tissues from humans and chimpanzees. We identified 90 TF genes with significantly different expression levels in human and chimpanzee brain among which the rapidly evolving KRAB-zinc finger genes are markedly over-represented. The differentially expressed TFs cluster within a robust regulatory network consisting of two distinct but interlinked modules, one strongly associated with energy metabolism functions, and the other with transcription, vesicular transport, and ubiquitination. Our results suggest that concerted changes in a relatively small number of interacting TFs may coordinate major gene expression differences in human and chimpanzee brain.
机译：人类与其他灵长类动物的区别在于认知能力和大脑的明显不同。这些差异与代谢变化相关，人类大脑中与能量相关的基因和代谢产物的相对上调证明了这一点。尽管尚未阐明这些进化变化的潜在机制，但关键转录因子（TF）活性的改变可能起着关键作用。为了评估这种可能性，我们分析了来自人类和黑猩猩的五个组织的微阵列数据。我们确定了90个TF基因在人和黑猩猩大脑中的表达水平显着不同，其中快速发展的KRAB-锌指基因明显过分代表。差异表达的TFs聚集在一个强大的调节网络中，该调节网络由两个截然不同但相互联系的模块组成，一个模块与能量代谢功能密切相关，另一个与转录，囊泡运输和泛素化相关。我们的结果表明，相对较少数量的相互作用TF的一致变化可能会协调人和黑猩猩大脑中的主要基因表达差异。

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  • 作者

    Katja Nowick; Tim Gernat; Eivind Almaas; Lisa Stubbs;

  • 作者单位

    Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, IL 61801 Department of Cell and Developmental Biology, University of Illinois at Urbana-Champaign, Urbana, IL 61801;

    Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, IL 61801 Department of Cell and Developmental Biology, University of Illinois at Urbana-Champaign, Urbana, IL 61801;

    Department of Biotechnology, Norwegian University of Science and Technology, N-7491 Trondheim, Norway;

    Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, IL 61801 Department of Cell and Developmental Biology, University of Illinois at Urbana-Champaign, Urbana, IL 61801;

  • 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    comparative transcriptomics; KRAB-zinc finger genes; primate evolution; gene regulatory network evolution;

    机译：比较转录组学KRAB-锌指基因;灵长类动物进化;基因调控网络进化;

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