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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Magnesium-aspartate-based crystallization switch inspired from shell molt of crustacean
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Magnesium-aspartate-based crystallization switch inspired from shell molt of crustacean

机译：基于甲壳动物壳蜕的灵感来自天门冬氨酸镁的结晶开关

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摘要

Many animals such as crustacean periodically undergo cyclic molt of the exoskeleton. During this process, amorphous calcium mineral phases are biologically stabilized by magnesium and are reserved for the subsequent rapid formation of new shell tissue. However, it is a mystery how living organisms can regulate the transition of the precursor phases precisely. We reveal that the shell mineralization from the magnesium stabilized precursors is associated with the presence of Asp-rich proteins. It is suggested that a cooperative effect of magnesium and Asp-rich compound can result into a crystallization switch in biomineralization. Our in vitro experiments confirm that magnesium increases the lifetime of amorphous calcium carbonate and calcium phosphate in solution so that the crystallization can be temporarily switched off. Although Asp monomer alone inhibits the crystallization of pure amorphous calcium minerals, it actually reduces the stability of the magnesium-stabilized precursors to switch on the transformation from the amorphous to crystallized phases. These modification effects on crystallization kinetics can be understood by an Asp-enhanced magnesium desolvation model. The interesting magnesium-Asp-based switch is a biologically inspired lesson from nature, which can be developed into an advanced strategy to control material fabrications.
机译：诸如甲壳类动物的许多动物定期经历外骨骼的周期性蜕变。在此过程中，无定形钙矿相被镁生物稳定，并保留用于随后新壳组织的快速形成。然而，活生物体如何精确调节前体相的转变是一个谜。我们揭示了从镁稳定的前体的壳矿化与富含Asp的蛋白质的存在有关。提示镁和富含Asp的化合物的协同作用可导致生物矿化中的结晶转换。我们的体外实验证实，镁可以延长溶液中无定形碳酸钙和磷酸钙的寿命，因此可以暂时关闭结晶。尽管仅Asp单体会抑制纯无定形钙矿物质的结晶，但实际上会降低镁稳定化前体的稳定性，从而开启从无定形到结晶相的转变。这些对结晶动力学的修饰作用可以通过Asp增强的镁去溶剂化模型来理解。有趣的基于镁-Asp的开关是从自然中汲取生物学灵感的课程，可以将其发展为控制材料制造的高级策略。

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  • 作者

    Jinhui Tao; Dongming Zhou; Zhisen Zhang; Xurong Xu; Ruikang Tang;

  • 作者单位

    Center for Biomaterials and Biopathways and Department of Chemistry, Zhejiang University, Hangzhou, Zhejiang 310027, China;

    Center for Biomaterials and Biopathways and Department of Chemistry, Zhejiang University, Hangzhou, Zhejiang 310027, China;

    Center for Biomaterials and Biopathways and Department of Chemistry, Zhejiang University, Hangzhou, Zhejiang 310027, China;

    Center for Biomaterials and Biopathways and Department of Chemistry, Zhejiang University, Hangzhou, Zhejiang 310027, China;

    Center for Biomaterials and Biopathways and Department of Chemistry, Zhejiang University, Hangzhou, Zhejiang 310027, China;

  • 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    biomineralization; calcium biominerals; phase transformation;

    机译：生物矿化;钙生物矿物质相变;

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