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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Recollection versus strength as the primary determinant of hippocampal engagement at retrieval
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Recollection versus strength as the primary determinant of hippocampal engagement at retrieval

机译:回忆与力量是检索时海马参与的主要决定因素

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摘要

We examined whether hippocampal activity in recognition relates to the strength of the memory or to recollective experience, a subject of considerable current debate. Participants studied word pairs and then made two successive recognition decisions on each item: first on the uncued target and then on the target presented with the studied cue word. We compared recollection and familiarity patterns of activation in fMRI for these decisions. Critically, our analyses attempted in two ways to equate perceived memory strength while varying the associative information available. First, activity for targets judged familiar before cueing was contrasted with activity for the same items in the second decision as a function of whether the targets converted to recollection or remained familiar when the context cues were provided. We found increased hippocampal activity following cueing only with recollective conversion. Second, we investigated whether hippocampal activity was modulated by the rated familiarity strength of cued items or whether it increased uniquely in recollection. Hippocampal activation was not modulated parametrically by familiarity strength and recollected items were associated with greater activity relative to highly familiar items. Together, our results support the notion that it is recollection of context, rather than memory strength, that underlies hippocampal engagement at retrieval.
机译:我们研究了识别中的海马活动是否与记忆力有关或与记忆力有关,这是当前争论的焦点。参与者研究了单词对,然后在每个项目上做出了两个连续的识别决定:首先是在未提示的目标上,然后是在带有研究提示词的目标上。我们对这些决定比较了功能磁共振成像中激活的回忆和熟悉模式。至关重要的是,我们的分析尝试以两种方式使感知的内存强度相等,同时改变可用的关联信息。首先,在提示中被判定为熟悉的目标的活动与第二项决定中相同项目的活动形成对比,这取决于目标是否转换为回忆或在提供上下文提示时是否保持熟悉。我们发现提示后仅通过记忆转换可以提高海马活动。其次,我们调查了海马活动是否受提示项目的额定熟悉程度调节或在回忆中是否独特地增加。相对于高度熟悉的物品,海马的激活不受熟悉程度的参量调节,并且回收的物品与更大的活动相关。总之,我们的研究结果支持这样一种观念,即在恢复时海马参与的基础是上下文的记忆而不是记忆力。

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    Krembil Neuroscience Centre, University Health Network, Fell Pavilion, 4-409, 399 Bathurst Street, Toronto, Ontario, Canada M5T 2S8 Department of Psychology, University of Toronto, 100 St. George Street, Toronto, Ontario, Canada M5S 3G3;

    Department of Psychology, University of Toronto, 100 St. George Street, Toronto, Ontario, Canada M5S 3G3 Rotman Research Institute and Department of Psychology, Baycrest Centre for Geriatric Care, 3560 Bathurst Street, Toronto, Ontario, Canada M6A 2E1;

    Department of Psychology, University of Toronto, 100 St. George Street, Toronto, Ontario, Canada M5S 3G3;

    Krembil Neuroscience Centre, University Health Network, Fell Pavilion, 4-409, 399 Bathurst Street, Toronto, Ontario, Canada M5T 2S8 Department of Psychology, University of Toronto, 100 St. George Street, Toronto, Ontario, Canada M5S 3G3;

  • 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    fMRI; medial temporal lobe; recognition memory;

    机译:功能磁共振成像;颞中叶识别记忆;

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