Interaction with host SGS3 is required for suppression of RNA silencing by tomato yellow leaf curl virus V2 protein

Efrat Glick; Avi Zrachya; Yael Levy; Anahit Mett; David Gidoni; Eduard Belausov; Vitaly Citovsky; Yedidya Gafni

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Interaction with host SGS3 is required for suppression of RNA silencing by tomato yellow leaf curl virus V2 protein

机译：需要与宿主SGS3相互作用才能抑制番茄黄叶卷曲病毒V2蛋白对RNA的沉默

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The V2 protein of tomato yellow leaf curl geminivirus (TYLCV) functions as an RNA-silencing suppressor that counteracts the innate immune response of the host plant. The host-cell target of V2, however, remains unknown. Here we show that V2 interacts directly with SISGS3, the tomato homolog of the Arabidopsis SGS3 protein (AtSGS3), which is known to be involved in the RNA-silencing pathway. SISGS3 genetically complemented an AtSGS3 mutation and restored RNA silencing, indicating that SISGS3 is indeed a functional homolog of AtSGS3. A point mutant of V2 that is unable to bind SISGS3 also lost its ability to suppress RNA silencing, suggesting a correlation between the V2-SISGS3 interaction in planta and the suppressor activity of V2.

机译：番茄黄叶卷曲双生病毒（TYLCV）的V2蛋白起RNA沉默抑制剂的作用，抵消宿主植物的先天免疫应答。但是，V2的宿主细胞目标仍然未知。在这里，我们显示V2与SISGS3直接相互作用，SISGS3是拟南芥SGS3蛋白（AtSGS3）的番茄同源物，已知它与RNA沉默途径有关。 SISGS3在基因上补充了AtSGS3突变并恢复了RNA沉默，表明SISGS3确实是AtSGS3的功能同源物。无法结合SISGS3的V2点突变体也失去了其抑制RNA沉默的能力，这表明植物体内V2-SISGS3相互作用与V2的抑制活性之间存在相关性。

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来源
《Proceedings of the National Academy of Sciences of the United States of America》 |2008年第1期|p.157-161|共5页
作者
Efrat Glick; Avi Zrachya; Yael Levy; Anahit Mett; David Gidoni; Eduard Belausov; Vitaly Citovsky; Yedidya Gafni;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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1. AC2 and AC4 proteins of Tomato yellow leaf curl China virus and Tobacco curly shoot virus mediate suppression of RNA silencing [J] . CUI Xiaofeng, ZHOU Xueping Chinese science bulletin . 2004,第24期

机译：番茄黄叶卷曲中国病毒和烟草卷曲新芽病毒的AC2和AC4蛋白介导RNA沉默的抑制。
2. AC2 and AC4 proteins of Tomato yellow leaf curl China virus and Tobacco curly shoot virus mediate suppression of RNA silencing [J] . CUI Xiaofeng, ZHOU Xueping Chinese science bulletin . 2004,第24期

机译：番茄黄叶卷曲中国病毒和烟草卷曲新芽病毒的AC2和AC4蛋白介导RNA沉默的抑制
3. V2 protein encoded by Tomato yellow leaf curl China virus is an RNA silencing suppressor [J] . ZhangJ., DongJ., XuY., Virus Research: An International Journal of Molecular and Cellular Virology . 2012,第1期

机译：番茄黄叶卷曲中国病毒编码的V2蛋白是RNA沉默抑制剂
4. PARTIAL CHARACTERIZATION AND HOST RANGE OF TOMATO YELLOW LEAF CURL VIRUS IN SOUTH FLORIDA [C] . Zhentu Ying, Michael J. Davis Annual Meeting of the Florida State Horticultural Society . 2001

机译：南佛罗里达州番茄黄叶卷曲病毒的部分表征及宿主范围
5. The mechanism of component recognition of bipartite geminiviruses: Genetic studies of the replication of squash leaf curl virus, and, Genetic and functional studies of squash leaf curl virus coat protein AR1 [D] . Qin, Shenwei 1996

机译：双向双子病毒的成分识别机制：南瓜卷叶病毒复制的遗传研究，以及南瓜卷叶病毒外壳蛋白AR1的遗传和功能研究
6. Correction for Glick et al. Interaction with host SGS3 is required for suppression of RNA silencing by tomato yellow leaf curl virus V2 protein [O] . 2009

机译：对Glick等人的校正与宿主SGS3的相互作用对于抑制番茄黄叶卷曲病毒V2蛋白抑制RNA沉默是必需的
7. Correction for Glick et al., Interaction with host SGS3 is required for suppression of RNA silencing by tomato yellow leaf curl virus V2 protein [O] . 2009

机译：对Glick等人的校正，与宿主SGS3相互作用对于抑制番茄黄叶卷曲病毒V2蛋白抑制RNA沉默是必需的

Interaction with host SGS3 is required for suppression of RNA silencing by tomato yellow leaf curl virus V2 protein

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