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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Slow-wave sleep and the risk of type 2 diabetes in humans
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Slow-wave sleep and the risk of type 2 diabetes in humans

机译：慢波睡眠和人类2型糖尿病的风险

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There is convincing evidence that, in humans, discrete sleep stages are important for daytime brain function, but whether any particular sleep stage has functional significance for the rest of the body is not known. Deep non-rapid eye movement (NREM) sleep, also known as slow-wave sleep (SWS), is thought to be the most "restorative" sleep stage, but beneficial effects of SWS for physical well being have not been demonstrated. The initiation of SWS coincides with hormonal changes that affect glucose regulation, suggesting that SWS may be important for normal glucose tolerance. If this were so, selective suppression of SWS should adversely affect glucose homeostasis and increase the risk of type 2 diabetes. Here we show that, in young healthy adults, all-night selective suppression of SWS, without any change in total sleep time, results in marked decreases in insulin sensitivity without adequate compensatory increase in insulin release, leading to reduced glucose tolerance and increased diabetes risk. SWS suppression reduced delta spectral power, the dominant EEG frequency range in SWS, and left other EEG frequency bands unchanged. Importantly, the magnitude of the decrease in insulin sensitivity was strongly correlated with the magnitude of the reduction in SWS. These findings demonstrate a clear role for SWS in the maintenance of normal glucose homeostasis. Furthermore, our data suggest that reduced sleep quality with low levels of SWS, as occurs in aging and in many obese individuals, may contribute to increase the risk of type 2 diabetes.
机译：有令人信服的证据表明，在人类中，离散的睡眠阶段对白天的大脑功能很重要，但是尚不清楚任何特定的睡眠阶段是否对身体的其余部分具有功能意义。深度非快速眼动（NREM）睡眠（也称为慢波睡眠（SWS））被认为是最“恢复性”的睡眠阶段，但尚未证明SWS对身体健康的有益作用。 SWS的启动与影响葡萄糖调节的激素变化相吻合，表明SWS对正常的葡萄糖耐量可能很重要。如果是这样，选择性抑制SWS应该会对葡萄糖稳态产生不利影响，并增加2型糖尿病的风险。在这里，我们表明，在年轻健康的成年人中，整夜选择性抑制SWS，而总睡眠时间没有任何变化，会导致胰岛素敏感性显着下降，而胰岛素释放却没有适当的补偿性增加，从而导致葡萄糖耐量降低和糖尿病风险增加。 SWS抑制降低了频谱频谱功率，SWS中占主导地位的EEG频率范围，并使其他EEG频段保持不变。重要的是，胰岛素敏感性降低的幅度与SWS降低的幅度密切相关。这些发现证明SWS在维持正常葡萄糖体内平衡中具有明显作用。此外，我们的数据表明，随着年龄的增长和许多肥胖个体的发生，低水平的SWS会降低睡眠质量，这可能会增加2型糖尿病的风险。

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