IP6K2 is a client for HSP90 and a target for cancer therapeutics development

David S. Shames; John D. Minna

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IP6K2 is a client for HSP90 and a target for cancer therapeutics development

机译：IP6K2是HSP90的客户，也是癌症治疗方法开发的目标

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The heat shock proteins (HSPs) comprise a family of highly conserved molecular chaper-ones that are central to protein structure homeostasis. HSPs prevent aggregation of cellular proteins, assist in protein folding, and act as "biochemical buffers" to guard proteins against diverse types of cellular stress including heat, changes in cellular pH, and hyp-oxia. The major functions of the HSPs in normal cells include coordination of higher-order interactions between "client" proteins and macromolecular machines, organelles, trafficking and metabolic vesicles, and structural proteins such as microtubules and actin filaments.

机译：热激蛋白（HSP）包含一系列高度保守的分子伴侣，它们是蛋白质结构稳态的关键。 HSP可防止细胞蛋白质聚集，协助蛋白质折叠，并充当“生化缓冲液”以保护蛋白质抵抗各种类型的细胞应激，包括热量，细胞pH值变化和低氧血症。正常细胞中HSP的主要功能包括协调“客户”蛋白与大分子机器，细胞器，运输和代谢囊泡以及结构蛋白（例如微管和肌动蛋白丝）之间的高级相互作用。

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《Proceedings of the National Academy of Sciences of the United States of America》 |2008年第5期|p.1389-1390|共2页
作者
David S. Shames; John D. Minna;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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6. IP6K2 is a client for HSP90 and a target for cancer therapeutics development [O] . David S. Shames, John D. Minna 2008

机译：IP6K2是HSP90的客户也是癌症治疗方法开发的目标
7. IP6K2 is a client for HSP90 and a target for cancer therapeutics development [O] . Shames, David S., Minna, John D. 2008

机译：IP6K2是HSP90的客户，也是癌症治疗方法开发的目标

IP6K2 is a client for HSP90 and a target for cancer therapeutics development

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