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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Circulation and long-term fate of functionalized, biocompatible single-walled carbon nanotubes in mice probed by Raman spectroscopy
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Circulation and long-term fate of functionalized, biocompatible single-walled carbon nanotubes in mice probed by Raman spectroscopy

机译：拉曼光谱法检测功能化，生物相容性单壁碳纳米管在小鼠体内的循环和长期命运

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摘要

Carbon nanotubes are promising new materials for molecular delivery in biological systems. The long-term fate of nanotubes intravenously injected into animals in vivo is currently unknown, an issue critical to potential clinical applications of these materials. Here, using the intrinsic Raman spectroscopic signatures of single-walled carbon nanotubes (SWNTs), we measured the blood circulation of intravenously injected SWNTs and detect SWNTs in various organs and tissues of mice ex vivo over a period of three months. Functionalization of SWNTs by branched polyethylene-glycol (PEG) chains was developed, enabling thus far the longest SWNT blood circulation up to 1 day, relatively low uptake in the reticuloendothelial system (RES), and near-complete clearance from the main organs in ≈2 months. Raman spectroscopy detected SWNT in the intestine, feces, kidney, and bladder of mice, suggesting excretion and clearance of SWNTs from mice via the biliary and renal pathways. No toxic side effect of SWNTs to mice was observed in necropsy, histology, and blood chemistry measurements. These findings pave the way to future biomedical applications of carbon nanotubes.
机译：碳纳米管是有望在生物系统中用于分子递送的新材料。目前尚不清楚静脉内注射到动物体内的纳米管的长期命运，这对这些材料的潜在临床应用至关重要。在这里，使用单壁碳纳米管（SWNTs）的固有拉曼光谱特征，我们测量了静脉注射的SWNTs的血液循环，并在三个月的时间内离体检测了小鼠体内各个器官和组织中的SWNTs。通过分支聚乙二醇（PEG）链对单壁碳纳米管的功能化得到开发，从而使迄今为止最长的单壁碳纳米管血液循环长达1天，网状内皮系统（RES）的吸收相对较低，并且从主要器官中几乎完全清除。 2个月。拉曼光谱法在小鼠的肠，粪便，肾脏和膀胱中检测到SWNT，表明SWNTs通过胆汁和肾脏途径从小鼠中排泄和清除。在尸检，组织学和血液化学测量中均未观察到SWNT对小鼠的毒副作用。这些发现为未来碳纳米管的生物医学应用铺平了道路。

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