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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >A biodegradable and biocompatible gecko-inspired tissue adhesive
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A biodegradable and biocompatible gecko-inspired tissue adhesive

机译：一种可生物降解和生物相容的壁虎启发组织粘合剂

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There is a significant medical need for tough biodegradable polymer adhesives that can adapt to or recover from various mechanical deformations while remaining strongly attached to the underlying tissue. We approached this problem by using a polymer poly(glycerol-co-sebacate acrylate) and modifying the surface to mimic the nanotopography of gecko feet, which allows attachment to vertical surfaces. Translation of existing gecko-inspired adhesives for medical applications is complex, as multiple parameters must be optimized, including: biocompatibility, biodegradation, strong adhesive tissue bonding, as well as compliance and con-formability to tissue surfaces. Ideally these adhesives would also have the ability to deliver drugs or growth factors to promote healing. As a first demonstration, we have created a gecko-inspired tissue adhesive from a biocompatible and biodegradable elastomer combined with a thin tissue-reactive biocompatible surface coating. Tissue adhesion was optimized by varying dimensions of the nanoscale pillars, including the ratio of tip diameter to pitch and the ratio of tip diameter to base diameter. Coating these nanomolded pillars of biodegradable elastomers with a thin layer of oxidized dextran significantly increased the interfacial adhesion strength on porcine intestine tissue in vitro and in the rat abdominal subfascial in vivo environment. This gecko-inspired medical adhesive may have potential applications for sealing wounds and for replacement or augmentation of sutures or staples.
机译：对于坚韧的可生物降解的聚合物胶粘剂存在重大的医学需求，该胶粘剂可以适应各种机械变形或从各种机械变形中恢复，同时仍然牢固地附着在下面的组织上。我们通过使用聚合物（甘油-癸二酸共癸二酸酯）聚合物并修饰表面以模仿壁虎脚的纳米形貌来解决此问题，从而可以附着在垂直表面上。由于必须优化多个参数，包括医学相容性，生物降解性，牢固的粘合剂组织粘合性以及对组织表面的顺应性和顺应性，因此现有的壁虎启发型粘合剂在医疗领域的转换非常复杂。理想地，这些粘合剂还将具有递送药物或生长因子以促进愈合的能力。作为第一个演示，我们从具有生物相容性和可生物降解性的弹性体与薄的具有组织反应性的生物相容性表面涂层相结合，创建了一种受壁虎启发的组织粘合剂。通过改变纳米级柱的尺寸，包括尖端直径与螺距的比以及尖端直径与基径的比，来优化组织粘附。在生物可降解弹性体的这些纳米成型支柱上覆盖一层氧化葡聚糖薄层，可显着提高体外和大鼠腹部亚筋膜下体内环境在猪肠组织上的界面粘附强度。这种受壁虎启发的医用胶粘剂可能具有潜在用途，可用于密封伤口以及替换或增加缝线或钉书钉。

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