...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >High levels of erythropoietin are associated with protection against neurological sequelae in African children with cerebral malaria
【24h】

High levels of erythropoietin are associated with protection against neurological sequelae in African children with cerebral malaria

机译：高水平的促红细胞生成素与非洲脑性疟疾儿童预防神经后遗症有关

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Cerebral malaria (CM) in children is associated with a high mortality and long-term neurocognitive sequelae. Both erythropoietin (Epo) and vascular endothelial growth factor (VEGF) have been shown to be neuroprotective. We hypothesized that high plasma and cere-brospinal fluid (CSF) levels of these cytokines would prevent neurological sequelae in children with CM. We measured Epo, VEGF, and tumor necrosis factor in paired samples of plasma and CSF of Kenyan children admitted with CM. Logistic regression models were used to identify risk and protective factors associated with the development of neurological sequelae. Children with CM (n = 124) were categorized into three groups: 76 without sequelae, 32 with sequelae, and 16 who died. Conditional logistic regression analysis matching the 32 patients with CM and neurological sequelae to 64 patients with CM without sequelae stratified for hemoglobin level estimated that plasma Epo (>200 units/liter) was associated with >80% reduction in the risk of developing neurological sequelae [adjusted odds ratio (OR) 0.18; 95% C.I. 0.05-0.93; P = 0.041]. Admission with profound coma (adjusted OR 5.47; 95% C.I. 1.45-20.67; P = 0.012) and convulsions after admission (adjusted OR 16.35; 95% C.I. 2.94-90.79; P = 0.001) were also independently associated with neurological sequelae. High levels of Epo were associated with reduced risk of neurological sequelae in children with CM. The age-dependent Epo response to anemia and the age-dependent protective effect may influence the clinical epidemiology of CM. These data support further study of Epo as an adjuvant therapy in CM.
机译：儿童脑疟疾（CM）与高死亡率和长期的神经认知后遗症有关。促红细胞生成素（Epo）和血管内皮生长因子（VEGF）已被证明具有神经保护作用。我们假设这些细胞因子的血浆和脑脊液（CSF）含量高会预防CM儿童的神经系统后遗症。我们在接受CM的肯尼亚儿童的血浆和CSF配对样本中测量了Epo，VEGF和肿瘤坏死因子。使用逻辑回归模型确定与神经后遗症发展相关的风险和保护因素。患有CM的儿童（n = 124）分为三组：76名无后遗症，32名有后遗症和16名死亡。根据条件Logistic回归分析，将32例CM和神经系统后遗症患者与64例无后遗症的CM患者按血红蛋白水平分层，估计血浆Epo（> 200单位/升）与神经系统后遗症风险降低> 80％相关[调整后的优势比（OR）0.18; 95％的C.I. 0.05-0.93； P ＝ 0.041]。深度昏迷入院（调整后OR 5.47; 95％C.I. 1.45-20.67; P = 0.012）和入院后惊厥（调整后OR 16.35; 95％C.I. 2.94-90.79; P = 0.001）也与神经系统后遗症相关。 Epo的高水平与CM儿童神经系统后遗症的风险降低相关。 Epo对贫血的年龄依赖性反应和年龄依赖性保护作用可能会影响CM的临床流行病学。这些数据支持进一步研究Epo作为CM的辅助治疗方法。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号