NEMO recognition of ubiquitinated Bel 10 is required for T cell receptor-mediated NF-κB activation

Chuan-Jin Wu; Jonathan D. Ashwell

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NEMO recognition of ubiquitinated Bel 10 is required for T cell receptor-mediated NF-κB activation

机译：T细胞受体介导的NF-κB激活需要NEMO识别泛素化Bel 10

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The mechanism by which the Carma1-Bcl10-MALT1 (CBM) complex couples T cell antigen receptor (TCR) signaling to IκB kinase (IKK) and NF-κB activation is not known. Here, we show that Bcl10 undergoes K63-linked polyubiquitination in response to T cell activation and subsequently binds NEMO, the regulatory subunit of IKK. This interaction requires the ubiquitin-binding activity of NEMO. The sites of Bcl10 ubiquitination were mapped to K31 and K63. Mutation of these residues did not affect TCR signaling-induced CBM complex assembly but prevented Bcl10 ubiquitination, NEMO binding, and NF-κB activation. Therefore, the regulated ubiquitination of Bcl10 and its recognition by NEMO are a critical link between the CBM complex, IKK recruitment, and NF-κB activation.

机译：Carma1-Bcl10-MALT1（CBM）复合物将T细胞抗原受体（TCR）信号传导至IκB激酶（IKK）和NF-κB激活的机制尚不清楚。在这里，我们显示Bcl10响应T细胞活化而经历K63连锁的多聚泛素化，随后结合NEMO（IKK的调节亚基）。这种相互作用需要NEMO的泛素结合活性。 Bcl10泛素化的位点被映射到K31和K63。这些残基的突变不会影响TCR信号诱导的CBM复合物组装，但会阻止Bcl10泛素化，NEMO结合和NF-κB活化。因此，Bcl10的调控泛素化及其对NEMO的识别是CBM复合物，IKK募集和NF-κB活化之间的关键环节。

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《Proceedings of the National Academy of Sciences of the United States of America》 |2008年第8期|p.3023-3028|共6页
作者
Chuan-Jin Wu; Jonathan D. Ashwell;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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2. Phosphorylation of Bcl10 Negatively Regulates T-Cell Receptor-Mediated NF-κB Activation [J] . Hu Zeng, Lie Di, Guoping Fu, Molecular and Cellular Biology . 2007,第14期

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5. Structural determinants required for receptor-mediated activation of G alpha(s). [D] . Marsh, Stephen Rabe. 1997

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6. NEMO recognition of ubiquitinated Bcl10 is required for T cell receptor-mediated NF-κB activation [O] . Chuan-Jin Wu, Jonathan D. Ashwell 2008

机译：NEMO识别泛素化的Bcl10是T细胞受体介导的NF-κB激活所必需的
7. NEMO recognition of ubiquitinated Bcl10 is required for T cell receptor-mediated NF-κB activation [O] . Wu, Chuan-Jin, Ashwell, Jonathan D. 2008

机译：NEMO识别泛素化的Bcl10是T细胞受体介导的NF-κB激活所必需的

NEMO recognition of ubiquitinated Bel 10 is required for T cell receptor-mediated NF-κB activation

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