Crystal structure of DNA-bound Co(III)·bleomycin B_2: Insights on intercalation and minor groove binding

Kristie D. Goodwin; Mark A. Lewis; Eric C. Long; Millie M. Georgiadis

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Crystal structure of DNA-bound Co(III)·bleomycin B_2: Insights on intercalation and minor groove binding

机译：DNA结合的Co（III）·博来霉素B_2的晶体结构：插层和小沟结合的见解。

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Bleomycins constitute a widely studied class of complex DNA cleaving natural products that are used to treat various cancers. Since their first isolation, the bleomycins have provided a paradigm for the development and discovery of additional DNA-cleaving

机译：博来霉素构成了广泛研究的一类复杂的DNA裂解天然产物，可用于治疗各种癌症。自首次分离以来，博来霉素为开发和发现额外的DNA切割提供了范例

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来源
《Proceedings of the National Academy of Sciences of the United States of America》 |2008年第13期|5052-5056|共5页
作者
Kristie D. Goodwin; Mark A. Lewis; Eric C. Long; Millie M. Georgiadis;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
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关键词
antitumor; DNA-binding; HOO-Co(III) bleomycin;

机译：抗肿瘤DNA结合;HOO-Co（III）博来霉素;

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2. The crystal structure of the TetR family transcriptional repressor SimR bound to DNA and the role of a flexible N-terminal extension in minor groove binding. [J] . Le TB, Schumacher MA, Lawson DM, Nucleic Acids Research . 2011,第21期

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5. Design, synthesis and analysis of DNA minor groove binding amino acid-benzimidazole conjugates. [D] . Li, Bo. 2009

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6. Crystal structure of DNA-bound Co(III)·bleomycin B2: Insights on intercalation and minor groove binding [O] . Kristie D. Goodwin, Mark A. Lewis, Eric C. Long, 2008

机译：DNA结合的Co（III）·博来霉素B2的晶体结构：嵌入和小沟结合的见解。
7. Crystal structure of DNA-bound Co(III)·bleomycin B2: Insights on intercalation and minor groove binding [O] . Goodwin, Kristie D., Lewis, Mark A., Long, Eric C., 2008

机译：DNA结合的Co（III）·博来霉素B2的晶体结构：嵌入和小沟结合的见解。

Crystal structure of DNA-bound Co(III)·bleomycin B_2: Insights on intercalation and minor groove binding

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