Enzymatic mechanism and product specificity of SET-domain protein lysine methyltransferases

Xiaodong Zhang; Thomas C. Bruice

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Enzymatic mechanism and product specificity of SET-domain protein lysine methyltransferases

机译：SET结构域蛋白赖氨酸甲基转移酶的酶促机理和产物特异性

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摘要

Molecular dynamics and hybrid quantum mechanics/molecular mechanics have been used to investigate the mechanisms of ~+AdoMet methylation of protein-Lys-NH_2 catalyzed by the lysine methyltransferase enzymes: histone lysine monomethyltrans-ferase SET7/9, R

机译：分子动力学和混合量子力学/分子力学已用于研究赖氨酸甲基转移酶催化的蛋白-Lys-NH_2〜+ AdoMet甲基化的机制：组蛋白赖氨酸单甲基转移酶SET7 / 9，R

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《Proceedings of the National Academy of Sciences of the United States of America》 |2008年第15期|5728-5732|共5页
作者
Xiaodong Zhang; Thomas C. Bruice;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
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关键词
molecular dynamics; QM/MM; SCCDFTB;

机译：分子动力学QM / MM;数码相机;

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专利

1. How Do SET-Domain Protein Lysine Methyltransferases Achieve the Methylation State Specificity? Revisited by Ab Initio QM/MM Molecular Dynamics Simulations [J] . Po Hu, Shenglong Wang, Yingkai Zhang Journal of the American Chemical Society . 2008,第12期

机译：SET域蛋白质赖氨酸甲基转移酶如何实现甲基化状态特异性？重新审视Ab Initio QM / MM分子动力学模拟
2. Mechanism of product specificity of AdoMet methylation catalyzed by lysine methyltransferases: Transcriptional factor p53 methylation by histone lysine methyltransferase SET7/9 [J] . Zhang XD, Bruice TC Biochemistry . 2008,第9期

机译：赖氨酸甲基转移酶催化AdoMet甲基化产物特异性的机理：组蛋白赖氨酸甲基转移酶SET7 / 9对转录因子p53甲基化的影响
3. Mechanism of histone methylation catalyzed by protein lysine methyltransferase SET7/9 and origin of product specificity [J] . Hao-Bo Guo, Hong Guo Proceedings of the National Academy of Sciences of the United States of America . 2007,第21期

机译：蛋白质赖氨酸甲基转移酶SET7 / 9催化组蛋白甲基化的机理及产物特异性的起源
4. Computational Prediction of Lysine Pupylation Sites in Prokaryotic Proteins Using Position Specific Scoring Matrix into Bigram for Feature Extraction [C] . Vineet Singh, Alok Sharma, Abel Chandra, Pacific Rim international conference on artificial intelligence . 2019

机译：使用位置特定得分矩阵转换为双字母组进行特征提取的原核蛋白中赖氨酸酰化位点的计算预测。
5. Development of novel methods and their utilization in the analysis of the effect of the n-terminus of human protein arginine methyltransferase 1 variant 1 on enzymatic activity, protein-protein interactions, and substrate specificity [D] . Suh-Lailam, Brenda Bienka 2011

机译：新方法的开发及其在分析人类蛋白质精氨酸甲基转移酶1变异体1的n端对酶活性，蛋白质间相互作用和底物特异性的影响中的用途
6. Enzymatic mechanism and product specificity of SET-domain protein lysine methyltransferases [O] . Xiaodong Zhang, Thomas C. Bruice 2008

机译：SET结构域蛋白赖氨酸甲基转移酶的酶促机理和产物特异性
7. Enzymatic mechanism and product specificity of SET-domain protein lysine methyltransferases [O] . Zhang, Xiaodong, Bruice, Thomas C. 2008

机译：SET结构域蛋白赖氨酸甲基转移酶的酶促机理和产物特异性

Enzymatic mechanism and product specificity of SET-domain protein lysine methyltransferases

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