Rational chemical design of the carbohydrate in a glycoconjugate vaccine enhances IgM-to-IgG switching

Hilde-Kari Guttormsen; Lawrence C. Paoletti; Keith G. Mansfield; Wojcieck Jachymek; Harold J. Jennings; Dennis L. Kasper

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Rational chemical design of the carbohydrate in a glycoconjugate vaccine enhances IgM-to-IgG switching

机译：糖缀合物疫苗中碳水化合物的合理化学设计可增强IgM-IgG转换

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Many pathogens are sheltered from host immunity by surface polysaccharides that would be ideal as vaccines except that they are too similar to host antigens to be immunogenic. The production of functional IgG is a desirable response to vaccines; because I

机译：许多病原体被表面多糖保护起来免受宿主免疫，表面多糖是理想的疫苗，除了它们与宿主抗原过于相似以致无法免疫。功能性IgG的产生是对疫苗的理想反应；因为我

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来源
《Proceedings of the National Academy of Sciences of the United States of America》 |2008年第15期|5903-5908|共6页
作者
Hilde-Kari Guttormsen; Lawrence C. Paoletti; Keith G. Mansfield; Wojcieck Jachymek; Harold J. Jennings; Dennis L. Kasper;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
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关键词
chemical modification; desialylation; group B Streptococcus; isotype switching; animal model;

机译：化学修饰脱唾液酸化B组链球菌;同型切换动物模型;

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2. Glycosylation of HIV-1 gp120 V3 loop: towards the rational design of a synthetic carbohydrate vaccine. [J] . Sirois S, Touaibia M, Chou KC, Current medicinal chemistry . 2007,第30期

机译：HIV-1 gp120 V3环的糖基化：朝着合理设计合成碳水化合物疫苗的方向发展。
3. Glycosylation of HIV-1 gp120 V3 Loop: Towards the Rational Design of a Synthetic Carbohydrate Vaccine [J] . Suzanne Sirois Mohamed Touaibia Kuo-Chen Chou Rene Roy Current Medicinal Chemistry . 2007,第30期

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4. Novel glycoconjugate vaccines based on rationally designed synthetic carbohydrate antigens [C] . Stwewart Campbell Vaccine technology IV . 2012

机译：基于合理设计的合成碳水化合物抗原的新型糖缀合物疫苗
5. 1. Design and synthesis of carbohydrate cancer vaccines based on biochemical modification of cancer cells. 2. Studies on the total synthesis of an antitumor saponin, OSW-1. [D] . Pan, Yanbin. 2005

机译：1.基于癌细胞的生化修饰的碳水化合物癌症疫苗的设计和合成。 2.关于抗肿瘤皂苷OSW-1的总合成的研究。
6. Rational chemical design of the carbohydrate in a glycoconjugate vaccine enhances IgM-to-IgG switching [O] . Hilde-Kari Guttormsen, Lawrence C. Paoletti, Keith G. Mansfield, 2008

机译：糖缀合物疫苗中碳水化合物的合理化学设计可增强IgM-IgG转换
7. Rational chemical design of the carbohydrate in a glycoconjugate vaccine enhances IgM-to-IgG switching [O] . Guttormsen, Hilde-Kari, Paoletti, Lawrence C., Mansfield, Keith G., 2008

机译：糖缀合物疫苗中碳水化合物的合理化学设计可增强IgM-IgG转换

Rational chemical design of the carbohydrate in a glycoconjugate vaccine enhances IgM-to-IgG switching

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