Drosophila germ-line modulation of insulin signaling and lifespan

Thomas Flatt; Kyung-Jin Min; Cecilia DAlterio; Eugenia Villa-Cuesta; John Cumbers; Ruth Lehmann; D. Leanne Jones; Marc Tatar

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Drosophila germ-line modulation of insulin signaling and lifespan

机译：果蝇种系对胰岛素信号传导和寿命的调节

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摘要

Ablation of germ-line precursor cells in Caenorhabditis elegans extends lifespan by activating DAF-16, a forkhead transcription factor (FOXO) repressed by insulin/insulin-like growth factor (IGF) signaling (IIS). Signals from the gonad might thus regulate

机译：秀丽隐杆线虫的生殖系前体细胞的消融通过激活DAF-16（一种受胰岛素/类胰岛素生长因子（IGF）信号传导（IIS）抑制的叉头转录因子（FOXO））来延长寿命。性腺的信号可能因此调节

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来源
《Proceedings of the National Academy of Sciences of the United States of America》 |2008年第17期|6368-6373|共6页
作者
Thomas Flatt; Kyung-Jin Min; Cecilia DAlterio; Eugenia Villa-Cuesta; John Cumbers; Ruth Lehmann; D. Leanne Jones; Marc Tatar;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类
关键词
aging; endocrine regulation; reproduction; longevity; metabolism;

机译：老化;内分泌调节;再生产;长寿;代谢;

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专利

1. Extension of Drosophila Lifespan by Astragalus polysaccharide through a Mechanism Dependent on Antioxidant and Insulin/IGF-1 Signaling [J] . Fujia Yang, Minghui Xiu, Shipei Yang, Evidence-based complementary and alternative medicine: eCAM . 2021,第a期

机译：通过依赖于抗氧化剂和胰岛素/ IGF-1信号传导的机制，通过黄芪多糖延伸果蝇寿命
2. Drosophila lifespan control by dietary restriction independent of insulin-like signaling. [J] . Min KJ, Yamamoto R, Buch S, Aging cell. . 2008,第2期

机译：果蝇的寿命不受饮食中胰岛素样信号的限制。
3. Drosophila lifespan control by dietary restriction independent of insulin-like signaling [J] . Kyung-Jin Min, Rochele Yamamoto, Susanne Buch, Aging cell. . 2008,第2期

机译：通过饮食限制控制果蝇的寿命，独立于胰岛素样信号
4. Modulation of insulin signaling by n-3 PUFA in chicken liver [C] . S.Tesseraud, S. Metayer Coustard, P. Chartrin, International Symposium on Energy and Protein Metabolism and Nutrition . 2013

机译：N-3 Pufa在鸡肝中的胰岛素信号调制
5. The Effects of Reduced Insulin/IGF-Like Signalling in the CNS on Lifespan, Brain Ageing and Stress Resistance in Drosophila Melanogaster [D] . Shaw, Tommy. 2021

机译：CNS在果蝇中CNS在CNS中降低的胰岛素/ IGF信号传导的影响，在果蝇Melanogaster中
6. Drosophila germ-line modulation of insulin signaling and lifespan [O] . Thomas Flatt, Kyung-Jin Min, Cecilia DAlterio, 2008

机译：果蝇种系对胰岛素信号传导和寿命的调节
7. Drosophila germ-line modulation of insulin signaling and lifespan [O] . Flatt, Thomas, Min, Kyung-Jin, D'Alterio, Cecilia, 2008

机译：果蝇种系对胰岛素信号传导和寿命的调节

Drosophila germ-line modulation of insulin signaling and lifespan

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