...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Ablation of thymic export causes accelerated decay of naive CD4 T cells in the periphery because of activation by environmental antigen
【24h】

Ablation of thymic export causes accelerated decay of naive CD4 T cells in the periphery because of activation by environmental antigen

机译：由于环境抗原的激活，胸腺输出的消融导致外周幼稚CD4 T细胞加速衰变

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

A model of chemical thymectomy by inducible Rag ablation was used to study peripheral T cell homeostasis. Induction of Rag ablation was efficient and complete, leading to cessation of thymic T cell production within 3-4 weeks. The decay of peripheral T cells became apparent with a delay of an additional 2-3 weeks and was entirely accounted for by loss of naieve T cells, whereas numbers of memory phenotype and regulatory T cells were not decreased. Naive CD4 T cells decayed with an average half-life of 50 days, whereas naive CD8 T cells exhibited a considerably longer half-life. The rapid decay of naive CD4 T cells was not caused by intrinsic survival differences compared with naive CD8 T cells, but was caused by changes in the lymphopenic environment resulting in higher microbial load and consequential activation. This finding suggests that in lymphopenic conditions involving compromised thymic function replenishment and survival of a naive CD4 T cell repertoire may be severely curtailed because of chronic activation. Such a scenario might play a role in the aging immune system and chronic viral infection, such as HIV infection, and contribute to loss of CD4 T cells and impaired immune function. As our data show, continued replenishment with cells from the thymus seems to be required to maintain efficient gut mucosal defense.
机译：使用诱导性Rag消融化学胸腺切除术的模型来研究外周T细胞稳态。 Rag消融的诱导是有效和完全的，导致在3-4周内停止胸腺T细胞的产生。外周T细胞的衰变变得明显，又延迟了2-3周，这完全是由于幼稚T细胞的丧失所致，而记忆表型和调节性T细胞的数量并未减少。幼稚的CD4 T细胞衰变平均半衰期为50天，而幼稚的CD8 T细胞表现出相当长的半衰期。与天然CD8 T细胞相比，天然CD4 T细胞的快速衰变不是由内在的生存差异引起的，而是由淋巴减少环境的变化引起的，从而导致较高的微生物负荷和相应的活化。这一发现表明，在涉及胸腺功能受损的淋巴细胞减少的情况下，由于慢性激活，可能会严重限制幼稚CD4 T细胞库的存活。这种情况可能在免疫系统老化和艾滋病毒等慢性病毒感染中起作用，并导致CD4 T细胞丢失和免疫功能受损。正如我们的数据所示，要维持有效的肠道粘膜防御，似乎需要持续补充来自胸腺的细胞。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号