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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Uncoupling of behavioral and autonomic responses after lesions of the primate orbitofrontal cortex
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Uncoupling of behavioral and autonomic responses after lesions of the primate orbitofrontal cortex

机译：灵长类动物眶额皮质损伤后行为和自主反应的分离

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摘要

Successful adaptation to changes in an animal's emotional and motivational environment depends on behavioral flexibility accompanied by changes in bodily responses, e.g., autonomic and endocrine, which support the change in behavior. Here, we identify the orbitofrontal cortex (OFC) as pivotal in the flexible regulation and coordination of behavioral and autonomic responses during adaptation. Using an appetitive Pavlovian task, we demonstrate that OFC lesions in the marmoset (ⅰ) impair an animal's ability to rapidly suppress its appetitive cardiovascular arousal upon termination of a conditioned stimulus and (ⅱ) cause an uncoupling of the behavioral and autonomic components of the adaptive response after reversal of the reward contingencies. These findings highlight the role of the OFC in emotional regulation and are highly relevant to our understanding of disorders such as schizophrenia and autism in which uncoupling of emotional responses may contribute to the experiential distress and disadvantageous behavior associated with these disorders.
机译：对动物情绪和动机环境变化的成功适应取决于行为灵活性以及伴随着身体反应的变化，例如自主和内分泌的变化，这些变化支持行为的变化。在这里，我们确定眶额叶皮层（OFC）在适应过程中灵活调节和协调行为和自主反应方面至关重要。使用具有吸引力的巴甫洛夫式任务，我们证明了mo猴中的OFC损伤（ⅰ）损害了动物在有条件的刺激终止后迅速抑制其有刺激性的心血管唤醒的能力，并且（ⅱ）导致了适应性行为和自主性成分的脱钩奖励突发事件冲销后的响应。这些发现凸显了OFC在情绪调节中的作用，并且与我们对诸如精神分裂症和自闭症等疾病的理解高度相关，在这些疾病中，情绪反应的分离可能会导致与这些疾病相关的体验困扰和不利行为。

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