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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Autoreactive IgG memory antibodies in patients with systemic lupus erythematosus arise from nonreactive and polyreactive precursors
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Autoreactive IgG memory antibodies in patients with systemic lupus erythematosus arise from nonreactive and polyreactive precursors

机译：系统性红斑狼疮患者的自身反应性IgG记忆抗体源自非反应性和多反应性前体

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摘要

Persistent autoantibody production in patients with systemic lupus erythematosus (SLE) suggests the existence of autoreactive humoral memory, but the frequency of self-reactive memory B cells in SLE has not been determined. Here, we report on the reactivity of 200 monoclonal antibodies from single lgG+ memory B cells of four SLE patients. The overall frequency of polyreactive and HEp-2 self-reactive antibodies in this compartment was similar to controls. We found 15% of IgG memory B cell antibodies highly reactive and specific for SLE-associated extractable nuclear antigens (ENA) Ro52 and La in one patient with serum autoantibody titers of the same specificity but not in the other three patients or healthy individuals. The germ-line forms of the ENA antibodies were non-self-reactive or polyreactive with low binding to Ro52, supporting the idea that somatic mutations contributed to autoantibody specificity and reactivity. Heterogeneity in the frequency of memory B cells expressing SLE-associated autoantibodies suggests that this variable may be important in the outcome of therapies that ablate this compartment.
机译：系统性红斑狼疮（SLE）患者持续产生自身抗体提示自身反应性体液记忆的存在，但尚未确定SLE中自身反应性记忆B细胞的频率。在这里，我们报道了来自四名SLE患者的单个IgG +记忆B细胞的200种单克隆抗体的反应性。在该隔室中多反应性抗体和HEp-2自反应性抗体的总频率与对照相似。我们发现，在一名具有相同特异性血清自身抗体滴度的患者中，有15％的IgG记忆B细胞抗体对SLE相关的可提取核抗原（ENA）Ro52和La具有高反应性和特异性，但在其他三名患者或健康个体中却没有。 ENA抗体的种系形式是非自反应性的或多反应性的，与Ro52的结合力低，这支持了体细胞突变有助于自身抗体特异性和反应性的观点。表达SLE相关自身抗体的记忆B细胞频率的异质性表明，该变量在消融该区室的治疗结果中可能很重要。

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