• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Microtransplantation of neurotransmitter receptors from postmortem autistic brains to Xenopus oocytes
【24h】

Microtransplantation of neurotransmitter receptors from postmortem autistic brains to Xenopus oocytes

机译：将神经递质受体从死后自闭症大脑微移植到非洲爪蟾卵母细胞

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Autism is a complex disorder that arises from the pervasive action of genetic and epigenetic factors that alter synaptic connectivity of the brain. Although GABA and glutamate receptors seem to be two of those factors, very little is known about the functional properties of the autistic receptors. Autistic tissue samples stored in brain banks usually have relatively long postmortem times, and it is highly desirable to know whether neurotransmitter receptors in such tissues are still functional. Here we demonstrate that native receptors microtransplanted from autistic brains, as well as de novo mRNA-expressed receptors, are still functional and susceptible to detailed electrophysiological characterization even after long postmortem intervals. The opportunity to study the properties of human receptors present in diseased brains not only opens new avenues toward understanding autism and other neurological disorders, but it also makes the microtransplantation method a useful translational system to evaluate and develop novel medicinal drugs.
机译：自闭症是一种复杂的疾病，由遗传和表观遗传因素的普遍作用引起，这些因素改变了大脑的突触连接性。尽管GABA和谷氨酸受体似乎是其中的两个因素，但对自闭症受体的功能特性知之甚少。存储在脑库中的自闭症组织样本通常具有较长的死后时间，因此非常需要知道此类组织中的神经递质受体是否仍在起作用。在这里，我们证明了从自闭症大脑微移植的天然受体，以及从头表达mRNA的受体，即使经过很长的尸检间隔，仍具有功能且易于进行详细的电生理学表征。研究患病大脑中人类受体特性的机会不仅为了解自闭症和其他神经系统疾病开辟了新途径，而且使微移植方法成为评估和开发新型药物的有用翻译系统。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号